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Synfacts 2006(11): 1096-1096  
DOI: 10.1055/s-2006-949391
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Machaeriol D

Contributor(s): Philip Kocienski, John Cooksey
Q. Wang, Q. Huang, B. Chen, J. Lu, H. Wang, X. She*, X. Pan*
Lanzhou University and Chinese Academy of Sciences, Lanzhou, P. R. of China
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Publication History

Publication Date:
24 October 2006 (online)

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Significance

Isolated from the stem bark of Machaerium multiflorum, (+)-machaeriol D is a member of the 5,6-secohexahydrodibenzopyran family of natural products. The She and Pan group reports the first enantioselective synthesis of (+)-machaeriol D making use of a highly regio- and stereoselective SN2′ reaction as the focal point of the synthesis.