Primary non-Hodgkin''s lymphoma in esophagus-a case report

A 57-year old man with gradually appeared dysphagia during one year period. Barium meal imaging of upper digestive tract and chest CT indicated esophageal stricture and incrassation of total esophageal wall, but there was no clinical evidence suggesting swelling of lymph nodes appearing in cervix, lung and mediastinum. 1 year later, incrassation of esophageal mocosa still existed in middle and distal part of esophagus by EGD examination. Then esophageal motility investigation and intra-luminal miniature probe sonography (MPS) were performed, it revealed that disorder of esophageal movement and 1.5˜2.0cm thickened mucosal layer of the esophagus with homogeneous hypoechoic structure. Followed by large piecemeal biopsy, the histo-pathological examination suggested: squamous epithelia was partially disappeared and replaced by same size, round or ovoid with clear nuclei proliferated lymphoid cells. Immunohistochemical and special staining indicated: I1415: AE1/AE3-, EMA-, LCA+, L26+, CD3-, CHG-, CD138-, κ+, λ-, Bcl2+, Bcl6-. Final result was primary Non-Hodgkin's lymphoma (NHL) microcyte type-B.