Pharmacopsychiatry 2006; 39(4): 159-160
DOI: 10.1055/s-2006-947183
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Acute Delusional Parasitosis under Treatment with Ciprofloxacin

A Case ReportT. Steinert1 , H. Studemund1
  • 1Centre for Psychiatry Weissenau, Department of Psychiatry I, University of Ulm, Ravensburg-Weissenau
Further Information

Publication History

Received: 13.1.2006 Revised: 13.4.2006

Accepted: 8.5.2006

Publication Date:
27 July 2006 (online)

Ciprofloxacin-induced psychoses have been described in some case reports, occurring sometimes in multi-morbid or personality disordered patients, but also in healthy subjects. We present a case of a 45-year-old man without previous mental disorder, who developed an acute delusional parasitosis after administration of ciprofloxacin. After discontinuation of ciprofloxacin, a complete and sustained remission could be observed within a few days, without the use of any psychopharmacologic medication. Possible modes of action are discussed.

References

  • 1 Abouesh A, Stone C, Hobbs W R. Antimicrobial-induced mania (anitbiomania): a review of spontaneous reports.  J Clin Psychopharmacol. 2002;  22 71-81
  • 2 Galatti L, Giustini E, Sessa A, Polimeni G, Solvo F, Spina E. Neuropsychiatric adverse drug reactions in general practice.  Pharmacopsychiatry. 2005;  38 41-68
  • 3 Grimm O, Alm B. A case of ciprofloxacin-induced acute polymorphic psychosis with a distinct deficit of the executive functions. Unpublished preprint 2006; http://cogprints.org/4187/. 
  • 4 Hollweg M, Kapfhammer H P, Krupinski  M, Möller H J. Psychopathologische Syndrome unter Behandlung mit Gyrasehemmern.  Nervenarzt. 1997;  68 38-47
  • 5 Jüngst G, Mohr R. Side effects of ofloxacin in clinical trials in postmarketing surveillance.  Drugs. 1987;  34 (Suppl 1) 144-149
  • 6 Mc Cue J D, Zandt J R. Acute psychoses associated with the use of ciprofloxacin and trimethoprim-sulfamethoxazole.  Ann J Med. 1991;  90 528-529
  • 7 Mulhall J P, Bergmann L S. Ciprofloxacin-induced acute psychosis.  Urology. 1995;  46 102-103
  • 8 Reeves R R. Ciprofloxacin induced psychosis.  Ann Phamacother. 1992;  26 930-931
  • 9 Rothenhäusler H B, Grieser B, Nollert G, Reichart B, Schelling G, Kapfhammer H P. Psychiatric and psychosocial outcome of cardiac surgery with cardiopulmonary bypass: a prospective 12-month follow-up study.  Gen Hosp Psychiatry. 2005;  27 18-28
  • 10 Trabert W. 100 years of delusional parasitosis. Meta-analysis of 1223 case reports.  Psychopathology. 1995;  28 238-246
  • 11 Tripathi A, Chen S I, O’ Sullivan S. Acute psychosis following the use of topical ciprofloxacin.  Arch Ophthalmol. 2002;  120 665-666
  • 12 Tsuji A, Sato H, Kume Y. Inhibitory effects of quinolone antibacterial agents on aminobutyric acid binding to receptor sites in rat brain membrane.  Antimicrob Agents Chemother. 1988;  32 190-194

Prof. Dr. med. Tilman Steinert

Center for Psychiatry Weissenau

University of Ulm

Weingartshofer Straße 2

88214 Ravensburg-Weissenau

Phone: +49 751 7601 2738

Fax: +49 751 7601 2706

Email: tilman.steinert@zfp-weissenau.de

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