Endoscopy 2007; 39: E39
DOI: 10.1055/s-2006-945081
Unusual cases and technical notes

© Georg Thieme Verlag KG Stuttgart · New York

Follicular lymphoma of the duodenum

P.  Born1 , M.  Vieth2 , M.  Stolte2
  • 1Abteilung für Innere Medizin, Kreiskrankenhaus Tirschenreuth, Germany
  • 2Institut für Pathologie, Klinikum Bayreuth, Germany
Further Information

Publication History

Publication Date:
07 February 2007 (online)

Although the gastrointestinal tract is the most common site of manifestation of extranodal lymphomas, intestinal lymphomas as a whole are rare. Among these entities, follicular lymphomas are even rarer [1] [2] [3] and show a female predominance [3].

We report the case of a 75-year-old woman who presented with cardiac arrhythmia. She also described nonspecific abdominal complaints.

To our surprise, at esophagogastroduodenoscopy of an otherwise normal-appearing duodenum, we found whitish, coarsely lumped, polypoid raised areas, some of which were solitary while others showed a clustered arrangement (Figure [1])

Histopathology, including immunohistochemical studies [4], revealed follicular lymphoma grade 1 (Figure [2]). Additional diagnostic procedures, such as computed tomography and bone marrow aspiration, showed no extraintestinal manifestation of the lymphoma.

Figure1 Duodenal mucosa with whitish, coarsely lumped, polypoid raised areas, some of which are solitary, while others show a clustered arrangement.

Figure 2 Follicular lymphoma of the duodenum with typical diffuse subepithelial infiltration by densely packed lymphocytes (hematoxylin and eosin stain; × 200).

Double-balloon or capsule endoscopy [5] was not performed. Conventional intestinoscopy showed that all accessible areas of the duodenum and the first part of the jejunum were involved; however, the peripapillary area remained free. At ileocoloscopy, the terminal ileum was also seen to be free from disease

Following discussion of this case with several international experts, it was decided to refrain from any kind of special therapy and instead to observe the course of the disease, which was expected to be benign [2] [3].



P. Born, MD

Department of Internal Medicine

County Hospital Tirschenreuth
St.-Peter-Str. 31
95643 Tirschenreuth

Fax: + 49-89-41404905

Email: peter.born@krankenhaus-tirschenreuth.de