PDF herunterladen
Synfacts 2006(8): 0760-0760  
DOI: 10.1055/s-2006-941930
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Garsubellin A

Contributor(s): Philip Kocienski, Thomas Snaddon
D. R. Siegel, S. J. Danishefsky*
Sloan-Kettering Institute for Cancer Research and Columbia University, New York, USA
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
21. Juli 2006 (online)

   Lizenzen und Reprints
Preview

Significance

Isolated from the wood of Garcinia subelliptica, Garsubellin A enhances choline acetyltransferase activity thus providing a potential new avenue for the treatment of Alzheimer’s disease. Stereoselective preparation of the oxygenated bicyclo[3.3.1]nonane core is particularly challenging. Noteworthy in this synthesis are the preparation of D by a selective para-allylation reaction, and access to J by iodocarbocyclization.