Am J Perinatol 2006; 23(5): 273-278
DOI: 10.1055/s-2006-941454
Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Retinopathy of Prematurity in Larger Preterm Infants

Po-Chiung Fang1 , Hsi-Kung Kuo1 , Tan-Yung Ko2 , Chih-Cheng Chen2 , Kao-Pin Hwang2 , Mei-Yung Chung2
  • 1Department of Ophthalmology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China
  • 2Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China
Further Information

Publication History

Publication Date:
09 May 2006 (online)

ABSTRACT

Severe retinopathy of prematurity (ROP) usually occurs in preterm infants with birthweight < 1500 g or gestational age < 31 weeks. However, some exceptions occur in larger preterm infants. In southern Taiwan, six larger preterm infants with gestational age older than 31 weeks and birthweight > 1500 g had stage III ROP in Chang Gung Memorial Hospital at Kaohsiung (Taiwan, Republic of China). All six infants were male and had received oxygen supplementation during hospitalization. Only one infant had received previous surgery and frequent packed red blood cell transfusions. Three infants received laser photocoagulation or cryotherapy, and all infants have good outcomes regardless of whether they received treatment. This report provides convincing evidence for expanding the screening criteria in our nursery and emphasizes the importance of assessing the risk of ROP for larger preterm infants.

REFERENCES

  • 1 Lee S K, Normand C, McMillan D for the Canadian Neonatal Network et al.. Evidence for changing guidelines for routine screening for retinopathy of prematurity.  Arch Pediatr Adolesc Med. 2001;  155 387-395
  • 2 Fleck B W, Wright E, Dhillon B et al.. An audit of the 1995 Royal College of Ophthalmologists guidelines for screening for retinopathy of prematurity applied retrospectively in one regional neonatal intensive care.  Eye. 1995;  9 31-35
  • 3 Goble R R, Jones H, Fielder A R. Are we screening too many babies for retinopathy of prematurity.  Eye. 1997;  11 509-514
  • 4 Hutchinson A K, Saunders R A, O'Neil J W, Lovering A, Wilson M E. Timing of initial screening examinations for retinopathy of prematurity.  Arch Ophthalmol. 1998;  116 608-612
  • 5 Jandeck C, Kellner U, Kossel H, Bartsch M, Versmold H T, Foerster M H. Retinopathy of prematurity in infants of birth weight > 2000 g after hemorrhagic shock at birth.  Br J Ophthalmol. 1996;  80 728-731
  • 6 Pheips D L. Retinopathy of prematurity. In: Fanaroff AA, Martin RL Neonatal-Perinatal Medicine. 7th ed. St. Louis; Mosby Year Book 2002: 1595-1599
  • 7 Rodriguez R J, Martin R J, Fanaroff A A. Respiratory distress syndrome and its management. In: Fanaroff AA, Martin RL Neonatal-Perinatal Medicine. 7th ed. St. Louis; Mosby Year Book 2002: 1001-1117
  • 8 Papile L A. Intracranial hemorrhage. In: Fanaroff AA, Martin RL Neonatal-Perinatal Medicine. 7th ed. St. Louis; Mosby Year Book 2002: 879-886
  • 9 Zahka K G, Patel C R. Congenital defects. In: Fanaroff AA, Martin RL Neonatal-Perinatal Medicine. 7th ed. St. Louis; Mosby Year Book 2002: 1138-1140
  • 10 Bancalari E H. Neonatal chronic lung disease. In: Fanaroff AA, Martin RL Neonatal-Perinatal Medicine. 7th ed. St. Louis; Mosby Year Book 2002: 1057-1070
  • 11 Kaul A, Balistreri W F. Necrotizing enterocolitis. In: Fanaroff AA, Martin RL Neonatal-Perinatal Medicine. 7th ed. St. Louis; Mosby Year Book 2002: 1299-1303
  • 12 Edwards M S. Postnatal bacterial infections. In: Fanaroff AA, Martin RL Neonatal-Perinatal Medicine. 7th ed. St. Louis; Mosby Year Book 2002: 706-718
  • 13 Wright K, Anderson M E, Walker E, Lorch V. Should fewer premature infants be screened for retinopathy of prematurity in the managed care era?.  Pediatrics. 1998;  102 31-34
  • 14 Fielder A R. The impact of low birth weight on the visual pathway.  Br J Ophthalmol. 1998;  82 1-4
  • 15 Gilbert C, Fielder A, Gordillo L et al.. Characteristics of infants with severe retinopathy of prematurity in countries with low, moderate, and high levels of development: implications for screening programs.  Pediatrics. 2005;  115 e518-e525
  • 16 Shastry B S, Prendergrast S D, Hatzer M K, Liu X, Trese M T. Identification of missense mutations in the Norrie disease gene associated with advanced retinopathy of prematurity.  Arch Ophthalmol. 1997;  115 651-655
  • 17 Blumenfeld L C, Siatkowski R M, Johnson R A, Feuer W J, Flynn J T. Retinopathy of prematurity in multiple gestation pregnancies.  Am J Ophthalmol. 1998;  125 197-203
  • 18 Hesse L, Eberl W, Schlaud M, Poets C F. Blood transfusion: iron load and retinopathy of prematurity.  Eur J Pediatr. 1997;  156 465-470
  • 19 Inder T E, Clemett R S, Austin N C, Graham P, Darlow B A. High iron status in very low birth weight infants is associated with an increased risk of retinopathy of prematurity.  J Pediatr. 1997;  131 541-544
  • 20 Brockhurst R J, Chishti M. Cicatricial retrolental fibroplasias: its occurrence without oxygen administration and in full term infants.  Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1975;  195 113-128
  • 21 Kraushar M F, Harper R G, Sia C G. Retrolental fibroplasia in a full term infant.  Am J Ophthalmol. 1975;  80 106-108
  • 22 Schulman J, Jampol L M, Schwatz H. Peripheral proliferative retinopathy without oxygen therapy in a full term infant.  Am J Ophthalmol. 1980;  90 509-514
  • 23 Kushner B J, Gloeckner E. Retrolental fibroplasias in full-term infants without exposure to supplemental oxygen.  Am J Ophthalmol. 1984;  97 148-153
  • 24 Criswick V G, Schepens C L. Familial exudative vitreretinopathy.  Am J Ophthalmol. 1969;  68 578-594
  • 25 Li Y, Muller B, Fuhrmann C et al.. The autosomal dominant familial exudative vitreoretinopathy locus maps on 11q and is closely linked to DIIS533.  Am J Hum Genet. 1992;  51 749-754
  • 26 Plager D A, Orgel I K, Ellis F D, Hartzer M, Trese M T, Shastry B S. X-linked recessive familial exudative vitreoretinopathy.  Am J Ophthalmol. 1992;  114 145-148
  • 27 Warburg M. Norrie's disease: a congenital progressive ocular-acoustico-cerebral degeneration.  Acta Ophthalmol (Copenh). 1966;  89 1-47
  • 28 Chen Z-Y, Battinelli E M, Woodruff G, Young I, Breakefield X O, Craig I W. Characterization of a mutation within the NDP gene in a family with a manifesting carrier.  Hum Mol Genet. 1993;  2 1727-1729
  • 29 Kellner U, Fuchs S, Bornfeld N, Foerster M H, Gal A. Ocular phenotypes associated with two mutations (R121W, C126X) in the Norrie disease gene.  Ophthalmic Genet. 1996;  17 67-74
  • 30 Reynolds J D, Hardy R J, Kennedy K A, Spencer R, van Heuven W AJ, Fielder A R. for the Light Reduction in Retinopathy of Prematurity (LIGHT-ROP) Cooperative Group . Lack of efficacy of light reduction in preventing retinopathy of prematurity.  N Engl J Med. 1998;  338 1572-1576
  • 31 The LIGHT-ROP Cooperative Group . The design of the multicenter study of light reduction in retinopathy of prematurity (LIGHT-ROP).  J Pediatr Ophthalmol Strabismus. 1999;  36 257-263
  • 32 Reynolds J D, Dobson V, Quinn G E for the CRYO-ROP and LIGHT-ROP Cooperative Groups et al.. Evidence-based screening criteria for retinopathy of prematurity: nature history data from the CRYO-ROP and LIGHT-ROP studies.  Arch Ophthalmol. 2002;  120 1470-1476
  • 33 Stout A U, Stout J T. Retinopathy of prematurity.  Pediatr Clin North Am. 2003;  50 77-87

Mei-Yung ChungM.D. 

Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung

123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan, Republic of China

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