RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2006(6): 0579-0579
DOI: 10.1055/s-2006-934478
DOI: 10.1055/s-2006-934478
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Asymmetric Allylation of Aldehydes Using a Chiral Cr(III) Complex
G. Xia, H. Yamamoto*
The University of Chicago, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
19. Mai 2006 (online)
Significance
Under mild Lewis acidic conditions, a wide variety of aldehydes were converted into the corresponding enantioenriched homoallylic alcohols using simple alkyl halides and a chromium complex. Yields and enantioselectivities are generally high for allylation, with good anti:syn ratios for crotylation in addition to high enantioselectivities for each diastereomer. The reaction tolerates a range of aromatic substitutents, although neither substrates with strongly electron-withdrawing nor Lewis basic substitutents were reported.