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Synfacts 2006(4): 0312-0312  
DOI: 10.1055/s-2006-932034
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Reblastatin

Contributor(s): Philip Kocienski, John Cooksey
I. E. Wrona, A. E. Gabarda, G. Evano, J. S. Panek*
Boston University, USA
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Publikationsdatum:
24. März 2006 (online)

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Significance

The Panek group report the enan­tioselective total synthesis of Reblastatin which features the first example of a Cu(I)-mediated Buchwald amidation reaction to form the 19-membered macrocyclic lactam present in the natural product.