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Synfacts 2006(3): 0208-0208  
DOI: 10.1055/s-2006-931968
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

Multi-Component Synthesis of 5H-Furoisoindole and Pyrrolo[3,4-f]indole Derivatives

Contributor(s): Victor Snieckus, Sunny Lai
K. Lu, T. Luo, Z. Xiang, Z. You, R. Fathi, J. Chen, Z. Yang
Peking University, P. R. of China and Vivoquest, Inc., New York, USA
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Publikationsverlauf

Publikationsdatum:
21. Februar 2006 (online)

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Significance

The synthesis of 5H-furoisoindole and pyrrolo[3,4-f]indole heterocycles by a combination of a four-component Ugi and intramolecular oxidative Diels-Alder (IMDA) reactions is reported. The scope of the process was further expanded to include the synthesis of thiazole-, benzofuran- and indole-based systems, illustrating its utility in the preparation of diverse and complex heterocycles.