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Synfacts 2005(3): 0275-0275  
DOI: 10.1055/s-2005-921596
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Latrunculin A

Contributor(s): Philip Kocienski, Thomas Snaddon
A. Fürstner*, L. Turet
Max-Planck-Institut für Kohlenforschung, Mülheim/Ruhr, Germany
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Publikationsdatum:
22. November 2005 (online)

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Significance

Latrunculins are a family of 2-thiazolidinone-containing macrolides isolated from the red sea sponge Negombata magnifica. As well as exhibiting significant cytotoxic and antiviral activity, they display potent and selective binding of the actin cytoskeleton in eukaryotic cells.