PDF herunterladen
Synfacts 2005(0): 0048-0048  
DOI: 10.1055/s-2005-869914
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Enantioselective Friedel-Crafts Alkylations by Strained Chiral Silacycle

Contributor(s): Hisashi Yamamoto, Matthew Boxer
S. Shirakawa, R. Berger, J. L. Leighton*
Columbia University, New York, USA
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
20. Juli 2005 (online)

   Lizenzen und Reprints

Significance

A chiral silicon Lewis acid has been utilized for the enantioselective Friedel-Crafts alkylation. The strained silacyle is effective at promoting the reaction for electron-rich aromatic systems under mild conditions.