ABSTRACT
Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease
that causes a heavy health and increasing economic burden both in the United States
and around the world. Most of the risk factors for COPD are well known and include
smoking, occupational exposures, air pollution, airway hyperresponsiveness, asthma,
and certain genetic variations, although many questions, such as why a minority of
smokers develop significant airway obstruction, remain. Major medical organizations
have agreed on a common definition of COPD, although newer measures, such as functional
status or exercise capability, have emerged as important in determining the prognosis
of COPD patients. In most of the world, COPD prevalence and mortality are still increasing
and will likely continue to rise in response to increases in smoking, particularly
by women and adolescents. Resources aimed at smoking cessation and prevention, COPD
education and early detection, and better treatment will be of the most benefit in
our continuing efforts against this important cause of morbidity and mortality.
KEYWORDS
Chronic obstructive pulmonary disease - epidemiology - prevalence - morbidity - mortality
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David M ManninoM.D.
Division of Pulmonary and Critical Care Medicine, University of Kentucky School of
Medicine
800 Rose St., MN 614, Lexington, KY 40536
eMail: dmmann2@email.uky.edu