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Synfacts 2005(0): 0028-0028  
DOI: 10.1055/s-2005-865376
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

Bis-acetylenic Ketones for the Synthesis of 1,2,4-Triazepine and Oxatriazaindenone Cores

Contributor(s): Victor Snieckus, F. Nowrouzi
M. F. A. Adamo*, J. E. Baldwin, R. M. Adlington
Oxford University, UK
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Publication History

Publication Date:
20 July 2005 (online)

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Significance

Bis-acetylenic ketones are used for the efficient (88-91%) one-pot synthesis of triazepine and oxa-triazaindenone cores representing two unusual heterocycles. The reactions are convenient, high yielding, and modular; therefore, they could be useful tools for the rapid generation of families of complex, diverse, and dense heterocyclic building blocks.