Planta Med 2005; 71(6): 554-560
DOI: 10.1055/s-2005-864158
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Antiproliferative Hopane and Oleanane Glycosides from the Roots of Glinus lotoides

Arafa I. Hamed1 , Sonia Piacente2 , Giuseppina Autore2 , Stefania Marzocco2 , Cosimo Pizza2 , Wieslaw Oleszek3
  • 1Botany Department, Aswan Faculty of Science, South Valley University, Aswan, Egypt
  • 2Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Fisciano, Salerno, Italy
  • 3Biochemistry Department, Institute of Plant Cultivation and Environmental Science, Pulawy, Poland
Further Information

Publication History

Received: August 9, 2004

Accepted: January 3, 2005

Publication Date:
21 June 2005 (online)


Three new hopane saponins, lotoidosides A - C (1 - 3), and four new oleanane saponins, lotoidosides D - G (4 - 7), were isolated from the roots of Glinus lotoides L. (Molluginaceae). Their structures were determined by extensive 1D- and 2D-NMR spectroscopy and ESI-MS analysis. The antiproliferative activity of compounds 1 - 7 was evaluated using three continuous murine and human culture cell lines J774.A1, HEK-293, WEHI-164. Compounds 1 and 3 - 7 showed significant cytotoxicity against the three cancer cell lines with IC50 values ranging from 0.018 to 0.62 μM, while compound 2 exerted a weak activity only against the cell line HEK-293.


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Prof. Cosimo Pizza

Dipartimento di Scienze Farmaceutiche

Università di Salerno

Via Ponte Don Melillo

84084 Fisciano



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