Planta Med 2005; 71(6): 535-542
DOI: 10.1055/s-2005-864155
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

New Cytotoxic Cyclobutanoid Amides, a New Furanoid Lignan and Anti-Platelet Aggregation Constituents from Piper arborescens

Ian-Lih Tsai1 , Fan-Pin Lee1 , Chin-Chung Wu1 , Chang-Yih Duh2 , Tsutomu Ishikawa3 , Jih-Jung Chen4 , Yu-Chang Chen1 , Hiroko Seki5 , Ih-Sheng Chen1
  • 1Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
  • 2Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China
  • 3Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan
  • 4Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China
  • 5Analytical Center, Chiba University, Chiba, Japan
Further Information

Publication History

Received: August 9, 2004

Accepted: February 13, 2005

Publication Date:
21 June 2005 (online)


Three new cyclobutanoid amides with trans-trans-trans configurations, piperarborenine C, piperarborenine D and piperarborenine E, and a new furanoid lignan, (+)-arborone, together with twelve known compounds, were isolated from the stems of Piper arborescens. The structures of these new compounds were determined by means of spectral analyses. Piperarborenine C, (+)-diayangambin, piplartine, piperolactam B, piperolactam C, aristolactam BIII, goniothalactam, and methyl trans-3,4,5-trimethoxycinnamate possessed anti-platelet aggregation activity in vitro. Among them, piplartine showed the most potent anti-platelet aggregation activity induced by collagen and showed an IC50 value of 21.5 μM. Piperarborenines A - E, piperarborenine, aristololactam BIII and goniothalactam showed significant cytotoxic activity (IC50 values < 4 μg/mL) against P-388, HT-29 and A549 cell lines in vitro.


Prof. Dr. Ih-Sheng Chen

School of Pharmacy

Kaohsiung Medical University



Republic of China

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