The Dopaminergic System, its Role in the Pathophysiology of Psychosis and Schizophrenia and Treatment by Atypical Antipsychotics

C. Czermak

doi:10.1055/s-2005-862630

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Pharmacopsychiatry 2005; 38 - 17
DOI: 10.1055/s-2005-862630

The Dopaminergic System, its Role in the Pathophysiology of Psychosis and Schizophrenia and Treatment by Atypical Antipsychotics

C Czermak ¹

¹Department of General Psychiatry 1, Landeskrankenhaus Sigmund Freud, Graz, Austria

Congress Abstract

The dopaminergic system is commonly assumed to play a central role in the pathophysiology of psychosis and schizophrenia. Besides influencing disorder-associated imbalances of the dopaminergic system, antipsychotics cause adverse drug reactions due to effects on other dopaminergic functions.

In this presentation, a detailed overview of the dopaminergic system with its various brain pathways and their neurobiological functions will be given. Dopaminergic effects of typical and atypical antipsychotics will be presented in view of the desired effects as well as in view of side effects.