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J Reconstr Microsurg 2004; 20(7): 545-553
DOI: 10.1055/s-2004-836126
Copyright © 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Prevention of Denervation atrophy by Nerve Implantation

Kazuki Ueda1 , Kiyonori Harii2
  • 1Department of Plastic and Reconstructive Surgery, Fukushima Medical University, Japan
  • 2Department of Plastic Surgery, Kyorin University, School of Medicine, Japan
Further Information

Publication History

Accepted: May 25, 2004

Publication Date:
09 November 2004 (online)

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Prevention of denervation atrophy in skeletal muscle by nerve implantation to a muscle belly was studied in a rat model. In the animals' legs, the tibial nerve branch innervating the lateral head of the gastrocnemius muscle was transected, and subsequently repaired by either simple nerve suture(n = 20) or interpositional nerve grafting (n = 20). The tibial nerve branch innervating the medial head was dissected out. The peroneal nerve was transected and implanted directly to the lateral head of the gastrocnemius muscle on one side and, as a control, the nerve on the other side was cut. After 6 months, isometric tension of the gastrocnemius muscle was greater on the implantation side than on the control side in the nerve-suture group (p < 0.05), but no tension difference between the two sides was observed in the nerve-graft group. The effects of neurotization by an implanted nerve may compete with those by a repaired nerve, when neurotization of the latter is delayed. Only when the time interval between neurotization by an implanted nerve and reinnervation by a repaired original nerve is short, does nerve implantation attenuate denervation atrophy.

KEYWORDS

Denervation atrophy - nerve implantation - direct neurotization

REFERENCES

  • 1 Gutmann E, Young J. The re-innervation of muscle after various periods of atrophy.  Anatomy. 1944;  78 15-43
    PubMedGoogle Scholar
  • 2 Dooley D M, Sharkey J. Electrostimulation of the nervous system for patients with demyelinating and degenerative diseases of the nervous system and vascular diseases of the extremities.  Appl Neurophysiol. 1977-78;  40 208-217
    PubMedGoogle Scholar
  • 3 Kanaya F, Tajima T. Effect of electrostimulation on denervated muscle.  Clin Orthop. 1992;  283 296-301
    PubMedGoogle Scholar
  • 4 Kern H, Frey M, Holle J et al.. Functional electrostimulation of paraplegic patients-1 year's practical application. Results in patients and experiences [in German].  Z Orthop. 1985;  123 1-12
    PubMedGoogle Scholar
  • 5 Terzis J. “Babysitters”: an exciting new concept in facial animation. In: Castri D Proceedings of the Sixth International Symposium on the Facial Nerve. Rio de Janeiro; Kugler and Ghedini 1988: 525
    Google Scholar
  • 6 Kamimura S. An experimental study on reinnervation of denervated muscles by direct nerve implantation [in Japanese].  Nippon Seikeigeka Gakkai Zasshi. 1975;  49 463-475
    PubMedGoogle Scholar
  • 7 Mochida K. An experimental study on direct nerve implantation into denervated muscle-the functional recovery and the site of implantation [in Japanese].  Nippon Seikeigeka Gakkai Zasshi. 1992;  66 1059-1072
    PubMedGoogle Scholar
  • 8 Kijima H, Tajima T, Seki T et al.. Experimental study of implantation of the motor nerve in the denervated muscle [in Japanese].  J Jpn Soc Surg Hand. 1989;  6 34-40
    PubMedGoogle Scholar
  • 9 Heineke H. Implantation of the nerve in the muscle [in German].  Archiv Klin Chir. 1914;  105 517-523
    PubMedGoogle Scholar
  • 10 Aitken J. Growth of nerve implants in voluntary muscle.  J Anat. 1950;  84 38-49
    PubMedGoogle Scholar
  • 11 Fex S, Thesleft S. The time required for innervation of denervated muscles by nerve implants.  Life Sci. 1967;  6 635-639
    CrossrefPubMedGoogle Scholar
  • 12 Guth L, Zalewski A, Brown W. Quantitative changes in cholinesterase activity of denervated sole plates following implantation of nerve into muscle.  Exp Neurol. 1966;  16 136-147
    CrossrefPubMedGoogle Scholar
  • 13 Sakellarides H, Sorbie C, James L. Reinnervation of denervated muscles by nerve transplantation.  Clin Orthop. 1972;  83 195-201
    PubMedGoogle Scholar
  • 14 Korneliussen H, Sommerschild H. Ultrastructure of the new neuromuscular junctions formed during reinnervation of rat soleus muscle by a “foreign” nerve.  Cell Tissue Res. 1976;  167 439-452
    PubMedGoogle Scholar
  • 15 Sakurai M, Campbell J. Reinnervation of denervated muscle by direct nerve implantation in cats.  Tohoku J Exp Med. 1971;  105 233-246
    PubMedGoogle Scholar
  • 16 Steindler A, Moines D. The method of direct neurotization of paralyzed muscle.  Am J Orthop Surg. 1915;  13 33-45
    PubMedGoogle Scholar
  • 17 Elsberg C. Experiments on motor nerve regeneration and the direct neurotization of paralyzed muscles by their own and foreign nerves.  Science. 1917;  45 318-320
    CrossrefPubMedGoogle Scholar
  • 18 Erlacher P. Direct and muscular neurotization of paralyzed muscle.  Am J Orthop Surg. 1915;  13 22-32
    PubMedGoogle Scholar
  • 19 Hoffman H. Effects of a fibrosis on the innervation of muscles by nerve implants.  J Comp Neurol. 1954;  100 411-455
    PubMedGoogle Scholar
  • 20 Stocky B. An experimental study of hyperneurotization.  Arch Neurol Psychiat. 1924;  11 113-120
    PubMedGoogle Scholar
  • 21 Brunelli G. Direct neurotization of severely damaged muscles.  J Hand Surg. 1982;  7 572-579
    PubMedGoogle Scholar
  • 22 Mackinnon S, McLean J, Hunter G. Direct muscle neurotization recovers gastrocnemius muscle function.  J Reconstr Microsurgery. 1993;  9 77-80
    Article in Thieme ConnectPubMedGoogle Scholar
  • 23 Serra J, Samayoa V, Valiente E et al.. Neurotization of the remaining latissimus dorsi muscle following muscle flap transplant.  J Reconstr Microsurg. 1988;  4 415-420
    PubMedGoogle Scholar
  • 24 Frey M, Gruber H, Holle J et al.. An experimental comparison of the different kinds of muscle reinnervation, nerve-suture, nerve implantation and muscular neurotization.  Plast Reconstr Surg. 1982;  69 656-667
    PubMedGoogle Scholar
  • 25 Saito A, Zacks S. Fine structure of neuromuscular junctions after nerve section and implantation of nerve in denervated muscle.  Exp Mol Pathol. 1969;  10 256-273
    PubMedGoogle Scholar
  • 26 Gwyn D, Aitken J. The formation of new motor endplates in mammalian skeletal muscle.  J Anat. 1966;  100 111-126
    PubMedGoogle Scholar
  • 27 Sorbie C. Reinnervation of paralyzed muscles by direct motor nerve implantation: an experimental study in the dog.  J Bone Joint Surg Br. 1969;  51 156-164
    PubMedGoogle Scholar
  • 28 Morioka H. An experimental study of direct nerve implantation in denervated muscle: reinnervation by formation of new motor endplates [in Japanese].  Nippon Seikeigeka Gakkai Zasshi. 1988;  62 43-55
    PubMedGoogle Scholar
  • 29 Frank E, Jansen J, Lomo T et al.. The interaction between foreign and original motor nerves innervating the soleus muscle of rats.  J Physiol. 1975;  247 725-743
    PubMedGoogle Scholar
  • 30 McArdle J. Complex end-plate potentials at the regenerating neuromuscular junction of the rat.  Exp Neurol. 1975;  49 629-638
    CrossrefPubMedGoogle Scholar
  • 31 Rotshenker S, McMahan V. Altered patterns of innervation in frog muscle after denervation.  J Neurocytol. 1976;  5 719-730
    CrossrefPubMedGoogle Scholar
  • 32 Mark R, Marotte L, Johnstone J. Reinnervated eye muscles do not respond to impulses in foreign nerves.  Science. 1970;  170 193-194
    PubMedGoogle Scholar
  • 33 Dennis M, Yip J. Formation and elimination of foreign synapses on adult salamander muscle.  J Physiol. 1978;  274 299-310
    PubMedGoogle Scholar
  • 34 Cass D, Sutton T, Mark R. Competition between nerves for functional connexions with axolotl muscles.  Nature. 1973;  243 201-203
    PubMedGoogle Scholar

Kazuki UedaM.D. 

Department of Plastic and Reconstructive Surgery, Fukushima Medical University

1 Hikarigaoka

Fukushima 960-1295, Japan

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