Pharmacopsychiatry 2003; 36 - 329
DOI: 10.1055/s-2003-825572

Possible changes of hippocampus and amygdala in borderline personality disorder: A structural magnetic resonance imaging study

T Zetzsche 1, UW Preuss 1, T Frodl 1, HJ Möller 1, EM Meisenzahl 1
  • 1Department of Psychiatry, Munich, Germany

Borderline personality disorder is often associated with emotional dysregulation. It is yet not clear if there exists a neurobiological basis for this disorder. The aim of our analysis is to compare volumes of hippocampus and amygdala in borderline personality subjects with those of age and sex-matched controls. For this purpose 25 female patients with a DSM IV diagnosis of borderline personality disorder according to the SCID II interview, were included. 25 age-matched healthy female subjects were recruited as controls. Volumetry of the gray and white matter of several brain regions were obtained with 1.5 T MRI using a volumetry software (BRAINS). Hippocampus and amygdala were delineated as regions of interest. In our study we will detect if hippocampus and amygdala are alterated as part of the limbic system in borderline patients. The results will be discussed in relationship to affective symptoms and impulsive behaviour in these patients.