Pharmacopsychiatry 2003; 36 - 266
DOI: 10.1055/s-2003-825509

Acute effects of corticosterone on BOLD signal: A pharmacological fMRI study in rats at 7 tesla

MI Schubert 1, S Droste 2, R Kalisch 1, F Holsboer 1, JHMH Reul 2, DP Auer 1
  • 1Magnetic Resonance Study Group
  • 2Section of Neuropsychopharmacology

Thirteen adrenalectomized rats were examined by phMRI at 7 Tesla in order to map local changes in BOLD signal after an acute stress challenge with corticosterone (CORT, n=7) compared to vehicle injection (CON, n=6). Regional time courses of CORT versus CON showed a relative increase (1.0–1.2%) in BOLD signal in medial prefrontal cortex/anterior cingulate (mPFC/ACC). Averaged time courses of volume of interests identified post hoc in SPM map confirmed a positive response difference of CORT/CON in orbitofrontal cortex, caudate-putamen and mPFC/ACC. Acute rises of CORT appear to regionally increase BOLD signal being in line with stress-related activation of prefrontal circuits.