Pharmacopsychiatry 2003; 36 - 245
DOI: 10.1055/s-2003-825488

Phospholipase A2 inhibition in the rat hippocampus disrupts short- and long-term memory processing

EL Schaeffer 1, WF Gattaz 1
  • 1Laboratory of Neuroscience, Department of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil

In early Alzheimer’s disease (AD) there is an impairment of episodic short-term (STM) and long-term memory (LTM). Decreased phospholipase A2 (PLA2) activity has been reported in the hippocampus of AD brains. In rat hippocampal slices, PLA2 has been implicated in mechanisms of synaptic plasticity involved in memory formation. Adult Wistar rats were bilaterally implanted with indwelling cannulae in the CA1 region of the dorsal hippocampus. After surgery, animals were submitted to one session of step-down inhibitory avoidance training. Animals received a bilateral infusion of a vehicle or of the PLA2 inhibitor MAFP given 30min before training. The animals were tested for STM and LTM after training. Infusion of MAFP impaired both STM and LTM processing of the inhibitory avoidance. These findings suggest that reduced PLA2 activity may contribute to the memory impairment in AD.