Pharmacopsychiatry 2003; 36 - 30
DOI: 10.1055/s-2003-825281

Cognitive function and psychomotor performance in schizophrenic patients

S Borgwardt 1, L Franke 1, R Uebelhack 1
  • 1Department of Psychiatry, Humboldt University (Charité), Berlin

Objective: The present study investigates the effects of typical (haloperidol, flupentixol, fluphenazine) and atypical neuroleptics (clozapine, olanzapine) on several cognitive and performance tasks in schizophrenic patients in comparison to drug-free patients and healthy subjects.

Methods: The performance of the subjects were evaluated by a comprehensive battery of validated psychometric tests in healthy subjects (n=51) and schizohrenic patients before (n=18) and at week 8 (n=26) of the treatment.

Results: Healthy subjects performed significantly better than the whole sample of schiziophrenic patients in almost all cognitive domains. Only in the group treated with typical neuroleptics the tendency to perseveration was highly dose-depended (n=14, rSp.=-0.886, p<0.001).

Conclusion: It is concluded that the disruptive effects of typical neuroleptics on cognitive function and psychomotor performance are dose-depending and that atypical neuroleptics had little or no effect on performance at the used dosage in comparison to drug-free schizophrenic patients.