Zusammenfassung
Die Phototherapie ist eine wesentliche Komponente der modernen dermatologischen Therapie
und hat wesentlich zur Besserung zahlreicher Dermatosen beigetragen. Der Ursprung
der Phototherapie ist empirischer Natur, und viele Entwicklungen haben sich auch noch
in letzter Zeit daraus abgeleitet. Einige phototherapeutische Konzepte beruhen aber
bereits auf den Fortschritten in der Photoimmunologie und Molekularbiologie. Auch
wenn wir noch weit davon entfernt sind, die Mechanismen der Phototherapie im Detail
zu verstehen, ist es offensichtlich, dass eine wesentliche Komponente der Phototherapie
die UV-induzierte Immunmodulation ist. UV-Strahlung ist in der Lage, das Immunsystem
in vielfältiger Weise zu beeinflussen. Es kann z. B. die Präsentation von Antigenen
inhibieren, die Freisetzung immunsuppressiver Zytokine induzieren und apoptotischen
Zelltod hervorrufen. Der folgendende Artikel beleuchtet die immunmodulatorischen Effekte
von UV-Strahlung.
Abstract
Phototherapy is a major therapeutic strategy in dermatology and has dramatically influenced
the treatment of many skin diseases. Therapeutic photomedicine has been largely empirical
and most of it is still empirical today. However, parts of it are already based on
the advances in photoimmunology and molecular biology. Although we are far away from
a detailed understanding of the mechanisms underlying phototherapy, there is increasing
evidence that phototherapy acts via the modulation of immune reactions. UV radiation
can affect immune reactions in several ways, e. g. by inhibiting antigen presentation,
inducing the release of immunosuppressive cytokines and by inducing apoptotic cell
death. The following article focuses primarily on the immunomodulatory effects of
UV radiation.
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Univ.-Prof. Dr. med. T. Schwarz
Hautklinik, Universitätsklinikum Münster
Von-Esmarch-Straße 58 · 48149 Münster
eMail: schwtho@uni-muenster.de
