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Pharmacopsychiatry 2003; 36(1): 7-11
DOI: 10.1055/s-2003-38085
Original Paper
© Georg Thieme Verlag Stuttgart · New York

Anxiety Induced by Repetitive Transcranial Magnetic Stimulation is Suppressed by Chronic Treatment of Paroxetine in Rats

K. Isogawa1 , M. Fujiki2 , J. Akiyoshi1 , T. Tsutsumi1 , Y. Horinouchi1 , K. Kodama1 , H. Nagayama1
  • 1Department of Neuropsychiatry, Oita Medical University, Oita, Japan
  • 2Department of Neurosurgery, Oita Medical University, Oita, Japan
Further Information

Publication History

Received: 3.10.2001 Revised: 25.3.2002

Accepted: 15.4.2002

Publication Date:
21 March 2003 (online)

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Repetitive transcranial magnetic stimulation (rTMS) has been shown to have a therapeutic effect on affective disorder and anxiety disorders. However, some reports have linked rTMS to a significant increase in anxiety in normal volunteers. This study investigates the effect of rTMS on anxiety and the use of acute and chronic paroxetine treatment on this animal model of anxiety. In normal rats, rTMS for 10 days induced anxiety, as shown by elevated plus maze, black and white box, and conditioned fear tests. This anxiety was suppressed by chronic, but not acute, paroxetine. These results suggest that rats receiving chronic rTMS treatment can be used as a model of anxiety and that the anxiety induced by rTMS might involve the serotonergic system.

Key words

Transcranial magnetic stimulation - anxiety - paroxetine - rats - chronic treatment - serotonin

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Jotaro Akiyoshi

Department of Neuropsychiatry

Oita Medical University

Hasama-Machi

Oita 879-5593

Japan

Phone: 81-97-586-5823

Fax: 81-97-549-3583

Email: akiyoshi@oita-med.ac.jp

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