Stenotrophomonas Maltophilia Infections

M. Cecilia Dignani; Monica Grazziutti; Elias Anaissie

doi:10.1055/s-2003-37920

Seminars in Respiratory and Critical Care Medicine, Table of Contents

Semin Respir Crit Care Med 2003; 24(1): 089-098
DOI: 10.1055/s-2003-37920

Stenotrophomonas Maltophilia Infections

M. Cecilia Dignani¹ , Monica Grazziutti² , Elias Anaissie³

¹FUNDALEU, Buenos Aires, Argentina
²FUNCEI, Buenos Aires, Argentina
³Myeloma Institute for Research and Treatment, The Arkansas Cancer Research Center, The University of Arkansas for Medical Sciences, Little Rock, Arkansas

Abstract

ABSTRACT

Stenotrophomonas maltophilia is a ubiquitous, gram-negative organism that causes hospital-acquired infections. Persons often come in contact with S. maltophilia through environmental water sources, including hospital tap water or faucets, and it has been associated with nosocomial outbreaks of infection. S. maltophilia often infects debilitated persons and those with underlying medical conditions, including immunosuppression. Manifestations of infection include pneumonia, often in mechanically ventilated patients, bacteremia, skin and soft tissue infection, urinary tract infection, and endocarditis. Treatment of S. maltophilia infection is difficult because the organism is resistant to a number of agents typically used for hospital-acquired infections. In vitro and clinical data indicate that trimethoprim-sulfamethoxazole is the agent of choice. Beta-lactamase inhibitors such as clavulanate are also active, and combination therapy may be indicated for certain serious infections due to S. maltophilia.

KEYWORDS

Stenotrophomonas maltophilia, nosocomial infections - immunocompromised host

Full Text

References

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