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Osteosynthese International 2001; 9(Suppl. 2): S93-S94
DOI: 10.1055/s-2001-17021
Experimentelle Untersuchungen zur intramedullären Osteosynthese

J.A.Barth Verlag in Medizinverlage Heidelberg GmbH & Co.KG

Bioactive implants with incorporated IGF-I and TGF-beta1 accelerate fracture healing

G. Schmidmaier, B. Wildemann, M. Lucke, H. Bail, M. Raschke
  • Department of Trauma and Reconstructive Surgery (Direktor: Prof. N.P. Haas), Charité Campus Virchow, Berlin
Further Information

Publication History

Publication Date:
12 September 2001 (online)

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Purpose

Bioactive implants could accelerate ¿bone metabolism and reduce local and systemic problems in fracture treatment and joint replacement. Former studies investigated the properties of a new ¿Poly(D,L-lactide) (PDLLA) coating on metallic implants for the local applica¿tion of drugs. The coating demonstrated a high mechanical stability during intramedullary insertion. The incorporated growth factors showed a continuous release of 80 % within six weeks after an initial peak [1]. In histomorphometric and biomechanical studies in rats, we found a significant acceleration of fracture healing by locally released rh-IGF-I and rh-TGF-β1 [2].

The purpose of this study was the evaluation of this bioactive coating of implants in a large animal model.

References

  • 1 Schmidmaier G. et al .Orthopaedic Research Society 1999
  • 2 Schmidmaier G. et al . Bone. 2001;  28 4
    PubMed

Dr. med. G. Schmidmaier

Department of Trauma and
Reconstructive Surgery
Charité Campus Virchow

Augustenburger Platz 1

D-13353 Berlin

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