Am J Perinatol 2001; 18(5): 293-298
DOI: 10.1055/s-2001-16993
ORIGINAL ARTICLES

Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Combination Thrombolytic and Anticoagulant Therapy for Bilateral Renal Vein Thrombosis in a Premature Infant

Nancy Weinschenk1 , Maria Pelidis2 , John Fiascone1
  • 1Division of Newborn Medicine, Department of Pediatrics, Floating Hospital for Children, Tufts University School of Medicine, Boston, Massachusetts
  • 2Division of Hematology and Oncology, Department of Pediatrics, Floating Hospital for Children, Tufts University School of Medicine, Boston, Massachusetts
Further Information

Publication History

Publication Date:
10 September 2001 (online)

ABSTRACT

We report a premature infant with bilateral renal vein thrombosis and renal failure at 1 month of age who underwent treatment with recombinant tissue plasminogen activator and heparin sulfate. Combination thrombolytic and anticoagulation therapy was complicated by an intraventricular and intraparenchymal cerebral hemorrhage without resolution of the renal vein thrombosis. With increasing reports of successful use of this therapy for venous thrombosis, we suggest caution and continued study of its use in the premature infant and newborn.

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