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Am J Perinatol 2001; 18(5): 237-240
DOI: 10.1055/s-2001-16988
ORIGINAL ARTICLES

Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Human Parvovirus B19 in Cord Blood of Premature Infants

Mayumi Koga1 3 , Takashi Matsuoka1 , Kumiko Katayama1 , Kanae Takeda1 3 , Masahiko Nakata2 3 , Masakatsu Sase2 3 , Hiroshi Kato2 3 , Susumu Furukawa1 3
  • 1Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan
  • 2Department of Gynecology, Yamaguchi University School of Medicine, Yamaguchi, Japan
  • 3Department of Perinatal Care Center for Mother and Child, Yamaguchi University School of Medicine, Yamaguchi, Japan
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Publication History

Publication Date:
10 September 2001 (online)

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ABSTRACT

We investigated whether intrauterine parvovirus B19 infection is associated with premature birth by evaluating parvovirus B19 antibodies and DNA in umbilical cord blood from 76 premature infants. We performed enzyme-linked immunoadsorbent (ELISA) and polymerase chain reaction (PCR) assays to detect B19-specific IgM antibodies and parvovirus DNA. No parvovirus DNA was detected in cord blood sera, and no sample was positive for anti-parvovirus B19 IgM antibodies. Parvovirus appears unlikely to lead to premature birth.

KEYWORD

Parvovirus - cord blood - premature infant - polymerase chain reaction

REFERENCES

  • 1 Cossart Y E, Field A M, Cant B, Widdows D. Parvovirus-like particles in human sera.  Lancet . 1975;  1 72-73
    PubMedGoogle Scholar
  • 2 Kelleher J F, Luban N LC, Mortimer P P, Kamimura T. Human serum parvovirus: a specific cause of aplastic crisis in children with hereditary spherocytosis.  J Pediatr . 1983;  102 720-722
    PubMedGoogle Scholar
  • 3 Anderson M J, Lewis E, Kidd I M, Hall S M, Cohen B J. An outbreak of erythema infectiosum associated with human parvovirus infection.  J Hyg . 1984;  93 85-93
    PubMedGoogle Scholar
  • 4 White D G, Woolf A D, Mortimer P P, Cohen B J, Blake D R, Bacon P A. Human parvovirus arthropathy.  Lancet . 1985;  1 419-421
    PubMedGoogle Scholar
  • 5 Brown T, Anand A, Ritchie L D, Clewley J P, Reid T MS. Intrauterine parvovirus infection associated with hydrops fetalis.  Lancet . 1984;  2 1033-1034
    PubMedGoogle Scholar
  • 6 Samra J S, Obhrai M S, Constantine G. Parvovirus in pregnancy.  Obstet Gynecol . 1989;  73 832-834
    PubMedGoogle Scholar
  • 7 Pustilnik T B, Cohen A W. Parvovius B19 infection in a twin pregnancy.  Obstet Gynecol . 1994;  83 834-836
    PubMedGoogle Scholar
  • 8 Cherry J D. Section 17 viral infections parvovirus. In: Feigin FD, Cherry JD, eds. Textbook of Pediatric Infectious Diseases Vol. 2. 4th ed. Philadelphia: W.B. Saunders 1998: 1620-1630
    Google Scholar
  • 9 Levy R, Weissman A, Blomberg G, Hagay Z. Infection by parvovirus B19 during pregnancy.  Obstet Gynecol Surv . 1997;  52 254-259
    CrossrefPubMedGoogle Scholar
  • 10 Schwarz T F, Nerlich A, Hottentraeger B. Parvovirus B19 infection of the fetus: histology and in situ hybridization.  Am J Clin Pathol . 1991;  96 121-126
    PubMedGoogle Scholar
  • 11 Weiner C P, Naides S J. Fetal survival after human parvovirus B19 infection: spectrum of intrauterine response in a twin gestation.  Am J Perinatol . 1992;  9 66-68
    PubMedGoogle Scholar
  • 12 Katz V L, McCoy M C, Kuller J A, Hansen W F. An association between fetal parvovirus B19 infection and fetal anomalies: a report of two cases.  Am J Perinatol . 1996;  13 43-45
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Ownby D R, McCullough J, Johnson C C, Peterson E L. Evaluation of IgA measurements as a method for detecting maternal blood contamination of cord blood samples.  Pediatr Allergy Immunol . 1996;  7 125-129
    PubMedGoogle Scholar
  • 14 Sevall J S. Detection of parvovirus B19 by dot-blot and polymerase chain reaction.  Mol Cell Probes . 1990;  4 237-246
    CrossrefPubMedGoogle Scholar
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