Zusammenfassung.
In dieser Übersicht wird die Evaluation der weiblichen Brust nach Aufbau mit Silikonmammaprothesen
mittels MR-Techniken vorgestellt. Ein Schwerpunkt liegt dabei auf der Defektdiagnostik,
d. h. dem Nachweis des so genannten „Gelblutens”, der intra- und der extrakapsulären
Ruptur. Daneben wird auf die MR-Detektion von Silikonomen (abgekapseltes Silikon)
und deren Abgrenzung von einem Malignom eingegangen und das typische MR-Erscheinungsbild
von chronischer Fremdkörperreaktion vorgestellt. „Gelbluten” ist mittels MR-Bildgebung
(MRT) allein nicht zuverlässig zu diagnostizieren. Für die intrakapsuläre Ruptur ist
das so genannte „Linguini-Zeichen” das einzig verlässliche Zeichen. Der Nachweis von
Silikon außerhalb der Prothesenkapsel beweist eine extrakapsuläre Ruptur. Der MR-spektroskopische
Nachweis von Silikon im Lebergewebe stützt bei kurzer Implantationszeit und unauffälliger
MRT die Diagnose eines ausgedehnten „Gelblutens” und bei langer Implantationszeit
von mehr als 10 Jahren und fehlendem „Linguini-Zeichen” die Diagnose einer Ruptur
durch eine aufgelöste Implantathülle. Die MR hat im Vergleich zu anderen Bildgebungsmodalitäten
die höchste Sensitivität und Spezifität in der Diagnostik von Implantatdefekten. Aus
Kostengründen sollte die MR allerdings nicht als Screeningmethode, sondern vor allem
bei sonographischem Verdacht auf Ruptur oder bei Zustand nach radikaler Mastektomie
und Aufbauplastik zum Einsatz kommen. In diesen Fällen stellt die MRT die Untersuchungsmodalität
der Wahl dar.
MRI and MRS in patients with silicon implants of the breast.
This paper reviews the evaluation of the breast of women by MR-techniques after implantation
with silicon gel protheses. The main topics are the diagnosis of implant defects such
as extensive “gel bleed” and intra- and extracapsular ruptures. Moreover, the MR-detection
of siliconomas (encapsulated silicone) and differentiation from malignomas as well
as MR-features of chronic foreign body reactions are presented. “Gel bleed” is difficult
to diagnose unambiguously by MRI alone. The “linguini” sign is the only reliable mans
to diagnose intracapsular ruptures. The presence of silicone outside the implant capsule
indicates extracapsular rupture. The MR-spectroscopic detection of silicone in the
liver suggests after short implantation times and a normal MR scan the diagnosis “gel
bleed”, and after longer implantation times of more than 10 years and missing “linguini”
sign the diagnosis of ruptures due to a dissolved shell of the implant. MRI, in comparison
to other imaging modalities, has the highest specificity and sensitivity in the diagnosis
of implant defects. Due to its high costs, however, MR is not suitable as a screening
tool and should only be used in cases of sonographic suspected rupture or after radical
mastectomy. In these cases MRI is the method of choice.
Schlüsselwörter:
MR-Tomographie - Mamma - Silikonmammaprothesen - Mammatumor - MR-Protonen-Spektroskopie
- Leber
Key words:
MR-Imaging - Breast - Silicone breast protheses - Breast tumour - MR-Proton spectroscopy
- Liver
Literatur
- 1
Smahel J.
Effect of expansion exercises on capsular contraction around silicone implants.
Aesth Plast Surg.
1979;
3
339-341
- 2
Busch H.
Silicone toxicology.
Semin Arthritis Rheum.
1994;
24
11-17
- 3
Peters W.
Current status of breast implant survival properties and the management of the woman
with silicone gel breast implants.
Can J Plast Surg.
2000;
8
54-67
- 4
Peters W J, Smith D C, Lugowski S.
Failure properties of 352 explanted silicone implants: a report of 300 patients.
Can J Plast Surg.
1996;
4
55-63
- 5
Sanchez-Guerrero J, Schur P H, Sergent J S, Liang M H.
Silicone breast implants and rheumatic disease - Clinical, immunologic, and epidemiologic
studies.
Arthritis Rheum.
1994;
35
158-168
- 6
Sanchez-Guerrero J, Golditz G A, Karlson E W, Hunter D J, Speizer F E, Liang M H.
Silicone breast implants and the risk of connective tissue diseases and symptoms.
New Engl J Med.
1995;
332
1666-1670
- 7
Borenstein D.
Siliconosis: A spectrum of illness.
Semin Arthritis Rheum.
1994;
24
1-7
- 8
Levine J J, Trachtmann H, Gold D M, Pettei M J.
Esophageal dysmotility in children breast-fed by mothers with silicone breast implants.
Long-term follow-up and response to treatment.
J Rheumat.
1996;
41
1600-1603
- 9
Levine J J, Ilowite N T, Pettei M J, Trachtman H.
Increased urinary NO3(-)+NO2- and neopterin excretion in children breast fed by mothers with silicone breast implants:
evidence for macrophage activation.
J Rheumat.
1996;
23
1083-1087
- 10
Gabriel S E, Woods J E, O’Fallon W M, Beard C M, Kurland L T, Melton L.
Complications leading to surgery after breast implantation.
New Engl J Med.
1997;
6
677-682
- 11
Caskey C I, Berg W A, Hamper U M, Sheth S, Chang B W, Anderson N D.
Imaging spectrum of extracapsular silicone: correlation of US, MR Imaging, mammographic,
and histopathologic findings.
RadioGraphics.
1999;
19
39-51
- 12
Bridges A J, Vasey F B.
Silicone breast implants.
Arch Int Med.
1993;
153
2638-2644
- 13
Ginsbarg G, Busch L C, Kuhnel W.
The nature of the collagenous capsules around breast implants.
Plast Reconstr Surg.
1979;
64
456-464
- 14
Janowsky E, Kupper L L, Hulka B S.
Meta-analysis of the relation between silicone implants and the risk of connective-tissue
diseases.
New Engl J Med.
2000;
342
781-790
- 15
Berg W A, Caskey C I, Hamper U M, Anderson N D, Chang B W, Sheth S. et al .
Diagnosing breast implant rupture with MR imaging, US and mammography.
RadioGraphics.
1993;
13
1323-1336
- 16
Gorczyca D P, DeBruhl N D, Ahn C Y, Hoyt A, Shaw W W, Bassett L W.
Silicone breast implant ruptures in an animal model: comparison of mammography, MR
imaging, US and CT.
Radiology.
1994;
190
227-237
- 17
Reynolds H E, Buckwalter K A, Jackson V P, Siwy B K, Alexander S G.
Comparison of mammography, sonography, and magnetic resonance imaging in the detection
of silicone-gel breast implant rupture.
Ann Plast Surg.
1994;
33
247-257
- 18
Weizer G, Malone R S, Netscher D T, Walker L E, Thornby J.
Utility of magnetic resonance imaging and ultrasonography in diagnosing breast implant
rupture.
Ann Plast Surg.
1995;
34
352-361
- 19
Quinn S F, Neubauer N M, Sheley R C, Demlow T A, Szurnowski J.
MR imaging of silicone breast implants: evaluation of prospective and retrospective
interpretations and interobserver agreement.
J Mag Reson Imaging.
1996;
6
213-218
- 20
Ahn C Y, DeBruhl N D, Gorezyca D P, Shaw W W, Bassett L W.
Comparative silicone breast implant evaluation using mammography, sonography, and
magnetic resonance imaging: experience with 59 implants.
Plast Reconstr Surg.
1994;
94
620-627
- 21
Garrido L, Kwong K K, Pfleiderer B, Crawley A P, Hulka C A, Whitman G L. et al .
Echo-planar chemical shift imaging of silicone gel prostheses.
Mag Reson Imag.
1993;
11
625-634
- 22
Schneider E, Chan T W.
Selective MR imaging of silicone with the three point Dixon technique.
Radiology.
1993;
87
89-93
- 23
Berg W A, Caskey C I, Hamper U M, Kuhlman J E, Anderson N D, Chang B W. et al .
Single- and double-lumen silicone breast implant integrity: a prospective evaluation
of MR and US criteria.
Radiology.
1995;
197
45-52
- 24
DeAngelis G A, De Lange E E, Miller L R, Morgan R F.
MR Imaging of Implants.
RadioGraphics.
1994;
14
783-794
- 25
Kaiser W A.
MR-Mammography.
Radiologe.
1993;
33
292-299
- 26
Heywang-Köbrunner S H.
Contrast enhanced magnetic resonance imaging of the breast.
Invest Radiology.
1994;
29
94-104
- 27
Pfleiderer B, Garrido L.
Silicone migration and accumulation in the liver of women with silicone gel-filled
breast implants.
Mag Reson Med.
1995;
33
8-17
- 28
Pfleiderer B, Campbell T, Hulka C A, Kopans D B, Lean C, Ackerman J L. et al .
Silicone Gel-filled Breast Implants in Women: Findings at H-1 MR-Spectroscopy.
Radiology.
1996;
201
277-283
- 29
Everson L I, Parantainen H, Detlie T E, , Olson P I, Landis G. et al .
Diagnosis of breast implant rupture: Imaging findings and relative efficiacies of
imaging techniques.
Am J Roentgen.
1994;
163
57-60
- 30
Truong L D, Cartwright J, Goodman M D, Woznicki D.
Silicone lymphadenopathy associated with augmentation mammaplasty.
Am J Surg Pathol.
1988;
12
484-491
- 31
Yu L T, Latorre G, Marotta J, Batich C, Hardt S N.
In vitro measurement of silicone bleed from breast implants.
Plast Reconstr Surg.
1995;
97
756-764
- 32
Mund D F, Farria D M, Gorczyca D P, DeBruhl N D, Ahn C Y, Shaw W W. et al .
MR Imaging of the breast in patients with silicone-gel implants: spectrum of findings.
Am J Roentgen.
1993;
161
773-778
- 33
de Camara D L, Sheridan J M, Kammer B A.
Rupture and aging of silicone gel breast implants.
Plast Reconstr Surg.
1993;
91
828-834
- 34
Rohrich R J, Adams W P, Beran S J, Rathakrishan R, Griffin J, Robinson J B.
An analysis of silicone gel-filled breast implants: Diagnosis and failure rates.
Plast Reconstr Surg.
1998;
102
2304-2310
- 35
Ahn C J, Ko C Y, Wagar E A, Wong R S, Shaw W W.
Clinical significance of intracapsular fluid in patients’ breast implants.
Ann Plast Surg.
1995;
35
455-457
- 36
Heywang S H, Wolf A, Pruss E, Hilbertz T, Eiermann W WP.
MR imaging of the breast with Gd-DTPA; use and limitations.
Radiology.
1989;
171
95-103
- 37
Goodmann C M, Cohen V, Thornby J, Netscher D.
The life span of silicone gel breast implants and a comparison of mammography, ultrasonography,
and magnetic resonance imaging in detecting implant rupture: a meta-analysis.
Ann Plast Surg.
1998;
41
577-585
- 38
Monticciolo D L, Nelson R C, Mickundan S, Hester R T.
MR detection of leakage from silicone breast implants: Value of a silicone-selective
pulse sequence.
Am J Roentgen.
1994;
163
51-56
- 39
Caffee H.
Discussion: Rupture and aging of silicone gel breast implants.
Plast Reconstr Surg.
1993;
91
835-836
- 40
Lorenz L, Stark G B, Hedde J P.
Stellenwert der Sonographie für die Aufdeckung von Komplikationen nach Implantation
von Silikongelkissen zur Mammaaugmentation bzw. -rekonstruktion.
Fortschr Röntgenstr.
1997;
166
233-237
- 41
Chung K C, Wilkins E G, Beil R J, Helvie M A, Ikeda D M, Oneal R M. et al .
Diagnosis of silicone gel breast implant rupture by ultrasonography.
Plast Reconstr Surg.
1996;
97
104-109
Priv. Doz. Dr. Bettina Pfleiderer
Institut für Klinische Radiologie
Universität Münster
Albert-Schweitzer-Straße 33
48129 Münster
Phone: 0251-83-56153
Fax: 0251-83-56145
Email: pfleide@uni-muenster.de