Planta Med 2001; 67(4): 370-371
DOI: 10.1055/s-2001-14318

© Georg Thieme Verlag Stuttgart · New York

1-O-Galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-β-D-glucose, a New Hepatoprotective Constituent from Combretum quadrangulare

I. Ketut Adnyana1 , Yasuhiro Tezuka1 , Suresh Awale1 , Arjun H. Banskota1 , Kim Qui Tran2 , Shigetoshi Kadota1,*
  • 1 Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
  • 2 National University Ho Chi Minh City, Ho Chi Minh City, Vietnam
Further Information

Publication History

May 19, 2000

August 19, 2000

Publication Date:
31 December 2001 (online)


A new gallic acid derivative, 1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-β-D-glucose (1) has been isolated from an H2O-fraction of MeOH extract of Combretum quadrangulare seeds. Compound 1 exhibited potent hepatoprotective activity against D-GalN/TNF-α-induced cell death in primary cultured mouse hepatocytes with an IC50 of 3.3 μM.


Prof. Dr. Shigetoshi Kadota

Department of Natural Products Chemistry

Institute of Natural Medicine

Toyama Medical and Pharmaceutical University

2630 Sugitani

Toyama 930-0194



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