Planta Med 2001; 67(4): 370-371
DOI: 10.1055/s-2001-14318
Letter

© Georg Thieme Verlag Stuttgart · New York

1-O-Galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-β-D-glucose, a New Hepatoprotective Constituent from Combretum quadrangulare

I. Ketut Adnyana1 , Yasuhiro Tezuka1 , Suresh Awale1 , Arjun H. Banskota1 , Kim Qui Tran2 , Shigetoshi Kadota1,*
  • 1 Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
  • 2 National University Ho Chi Minh City, Ho Chi Minh City, Vietnam
Further Information

Publication History

May 19, 2000

August 19, 2000

Publication Date:
31 December 2001 (online)

Abstract

A new gallic acid derivative, 1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-β-D-glucose (1) has been isolated from an H2O-fraction of MeOH extract of Combretum quadrangulare seeds. Compound 1 exhibited potent hepatoprotective activity against D-GalN/TNF-α-induced cell death in primary cultured mouse hepatocytes with an IC50 of 3.3 μM.

References

  • 1 Pettit G R, Singh S B, Boyd M R, Hamel E, Pettit R K, Schmidt J M, Hogan F. Antineoplastic agents. 291. Isolation and synthesis of combrestatins A-4, A-5, and A-6 (1a).  Journal of Medicinal Chemistry. 1995;  38 1666-72
  • 2 Medicinal Plants in Vietnam. Tran K, editor WHO Regional Office for the Western Pacific Manila, and Institute of Materia Medica Hanoi, Science and Technology Publishing House, Hanoi. 1990: 119
  • 3 Banskota A H, Tezuka Y, Adnyana I K, Xiong Q, Hase K, Tran K Q, Tanaka K, Saiki I, Kadota S. Hepatoprotective effect of Combretum quadrangulare and its constituents.  Biological Pharmaceutical Bulletin. 2000;  23 456-60
  • 4 Xiong Q, Hase K, Tezuka Y, Tani T, Namba T, Kadota S. Hepatoprotective activity of phenylethanoid from Cistanche deserticola .  Planta Medica. 1998;  64 120-5
  • 5 Xiong Q, Fan W, Tezuka Y, Adnyana I K, Stampoulis P, Hattori M, Namba T, Kadota S. Hepatoprotective effect of Apocynum venetum and its active constituents.  Planta Medica. 2000;  66 127-33
  • 6 Adnyana I K, Tezuka Y, Banskota A H, Xiong Q, Tran K Q, Kadota S. Quadranoside I - V, new triterpene glucosides from the seeds of Combretum quadrangulare .  Journal of Natural Products. 2000;  63 496-500
  • 7 Adnyana I K, Tezuka Y, Awale S, Banskota A H, Tran K Q, Kadota S. Quadranoside VI - XI, six new triterpene glucosides from the seeds of Combretum quadrangulare .  Chemical Pharmaceutical Bulletin. 2000;  48 1114-20
  • 8 Nonaka G, Nishioka I. Tannins and related compounds. X. Rhubarb (2): Isolation and structures of a glycerol gallate, gallic acid and glucoside gallates, galloylglucoses and isolindleyin.  Chemical Pharmaceutical Bulletin. 1983;  31 1652-58
  • 9 Silverstein R M, Webster F X. Spectrometric Identification of Organic Compounds Sixth Edition. New York; John Wiley & Sons 1998: pp. 200

Prof. Dr. Shigetoshi Kadota

Department of Natural Products Chemistry

Institute of Natural Medicine

Toyama Medical and Pharmaceutical University

2630 Sugitani

Toyama 930-0194

Japan

Email: kadota@ms.toyama-mpu.ac.jp

Fax: +81-76-434-5059

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