Abstract
A new gallic acid derivative, 1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-β-D-glucose (1) has been isolated from an H2O-fraction of MeOH extract of Combretum quadrangulare seeds. Compound 1 exhibited potent hepatoprotective activity against D-GalN/TNF-α-induced cell death
in primary cultured mouse hepatocytes with an IC50 of 3.3 μM.
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Prof. Dr. Shigetoshi Kadota
Department of Natural Products Chemistry
Institute of Natural Medicine
Toyama Medical and Pharmaceutical University
2630 Sugitani
Toyama 930-0194
Japan
Email: kadota@ms.toyama-mpu.ac.jp
Fax: +81-76-434-5059