Am J Perinatol 2001; 18(2): 113-116
DOI: 10.1055/s-2001-13637
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Transient Fetal Hypothyroidism Due to Direct Fetal Administration of Amiodarone for Drug Resistant Fetal Tachycardia

Jesse Vanbesien, Ann Casteels, Adel Bougatef, Luc De Catte, Walter Foulon, Sonja De Bock, Johan Smitz, Jean De Schepper
  • Academisch Ziekenhuis Kinderen, Vrije Universiteit Brussel, Brussels-Jette, Belgium
Further Information

Publication History

Publication Date:
31 December 2001 (online)

ABSTRACT

Amiodarone, an anti-arrhythmic drug that contains 39% iodine, is rarely known to cause negative effects on fetal thyroid function after gestational exposure, when given orally to a pregnant woman. Two cases of fetal hypothyroidism after gestational exposure to amiodarone by direct fetal intravenous route are described here.

REFERENCES

  • 1 De Catte L, De Wolf D, Smitz J, Bougatef A, De Schepper J, Foulon W. Fetal hypothyroidism as a complication of amiodarone treatment for persistent fetal supraventricular tachycardia.  Prenat Diagn . 1994;  14 762-765
  • 2 Mason J W. Amiodarone.  N Engl J Med . 1987;  316 455-466
  • 3 Plomp T A, Vulsma T, de Vijlder J M J. Use of amiodarone during pregnancy.  Eur J Obstet Gynecol Reprod Biol . 1992;  43 201-207
  • 4 Harjai K J, Licata A A. Effects of amiodarone on thyroid function.  Ann Intern Med . 1997;  126 63-73
  • 5 Valenisise H, Civitella C, Garzetti G G, Romanini C. Amiodarone treatment in pregnancy for dilatative cardiomyopathy with ventricular malignant extrasystole and normal maternal and neonatal outcome.  Prenat Diagn . 1992;  12 705-708
  • 6 Trip M D, Wiersinga W, Plomp T A. Incidence, predictability and pathogenesis of amiodarone-induced thyrotoxicosis and hypothyroidism.  Am J Med . 1991;  91 507-511
  • 7 De Wolf D, De Schepper J, Verhaaren H, Deneyer M, Smitz J, Sacre-Smits L. Congenital hypothyroid goiter and amiodarone.  Acta Paediatr Scand . 1988;  77 616-618
  • 8 Matsumura L K, Born D, Kunii I S, Franco D B, Maciel R MB. Outcome of thyroid function in newborns from mothers treated with amiodarone.  Thyroid . 1992;  2 279-281
  • 9 Darwiche A, Vanliefeinghen P, Lemery D, Paire M, Lusson J R. Amiodarone et tachycardie supraventriculaire foetale: a propos d'un cas avec hypothyroidie néonatale.  Arch Fr Pediatr . 1992;  49 729-731
  • 10 Grosso D, Berarde R, Cioni M, Morgese G. Transient neonatal hypothyroidism after gestational exposure to amiodarone: a follow-up of two cases.  J Endocrinol Invest . 1998;  21 699-702
  • 11 Magee L A, Downar E, Sermer M, Boulton B C, Allen L C, Koren G. Pregnancy outcome after gestational exposure to amiodarone in Canada.  Am J Obstet Gynecol . 1995;  172 1307-1311
  • 12 Noia G, De Santis M, Tocci A. Early prenatal diagnosis and therapy of fetal hypothyroid goiter.  Fetal Diagn Ther . 1992;  7 138-143
  • 13 Fisher D A, Klein A H. Thyroid development and disorders of thyroid function in the newborn.  N Engl J Med . 1981;  304 702-712
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