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Semin Respir Crit Care Med 2000; Volume 21(Number 05): 365-374
DOI: 10.1055/s-2000-9403
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Epidemiology of Lung Cancer with Special Reference to Genetics, Bioassays, Women, and Developing Countries

Grier P. Page1,2 , Judith L. Green2 , Daniel Lackland1
  • 1Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, South Carolina
  • 2Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina
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Publication History

Publication Date:
31 December 2000 (online)

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ABSTRACT

The twentieth century may be looked back upon as the century of lung cancer. At the beginning of the century lung cancer was quite rare, but this century the rates have increased approximately 10-fold and it is the second most common type of cancer and has become the leading cause of death due to cancer in the United States. The rate of lung cancer among U.S. women continues to rise, in contrast rates in U.S. men have been declining since about 1990. Cigarette smoking accounts for 85-90% of lung cancer deaths in the United States. However, only 10-15% of smokers eventually develop lung cancer. In the past 25 years, since the U.S. Surgeon General's ground breaking report in 1964, overall smoking rates have been declining, but smoking still remains a significant behavior. More troubling, the rates of smoking continue to increase in many parts of the world. Advances in molecular biology and early diagnosis have increased the understanding of lung cancer etiology and may be effective in uncovering more efficient detection and treatment regimens. These advances will hopefully make lung cancer as uncommon at the end of the twenty-first century, as it was at the beginning of the twentieth century.

KEYWORD

Lung cancer - genetics - bioassays - women - developing countries

REFERENCES

  • 1 Doll R, Hill A. Smoking and carcinoma of the lung.  BMJ . 1950;  2 739-748
    CrossrefPubMedGoogle Scholar
  • 2 Levin M, Goldstein H, Gerhardt P. Cancer and tobacco smoking. A preliminary report.  JAMA . 1950;  143 336-338
    PubMedGoogle Scholar
  • 3 Wynder E L, Graham E. Tobacco smoking as a possible etiological factor in bronchiogenic carcinoma. A study of six hundred and eighty-four proved cases.  JAMA . 1950;  143 329-346
    PubMedGoogle Scholar
  • 4 U.S. Department of Health Education and Welfare. Smoking and Health: Report of the advisory committee to the Surgeon General of the Public Health Service Washington, DC: U.S. Government Printing Office; 1964
  • 5 Alberg A J, Samet J M. Epidemiology of lung cancer. In: Kane M, Bunn P, eds. Biology of Lung Cancer New York: Marcel Dekker 1998: 11-52
    Google Scholar
  • 6 The Centers for Disease Control and Prevention. Cigarette smoking among adults-United States, 1997.  Morbid Mort Wkly Rep . 1999;  48 993-996
    PubMedGoogle Scholar
  • 7 The Centers for Disease Control and Prevention. Tobacco Use among high school student-United States, 1997.  Morbid Mortal Wkly Rep . 1998;  47 229-233
    PubMedGoogle Scholar
  • 8 The Centers for Disease Control and Prevention. Cigarette smoking among high school students-11 states, 1991-1997.  Morbid Mortal Wkly Rep . 1999;  48 686-692
    PubMedGoogle Scholar
  • 9 Doll R, Peto R. The causes of cancer: Quantitative estimated of avoidable risks of cancer in the United States today.  JNCI . 1981;  66 1191-1308
    PubMedGoogle Scholar
  • 10 Damber L A, Larsson L G. Occupation and male lung cancer: A case-control study in northern Sweden.  Br J Ind Med . 1987;  44 446-453
    PubMedGoogle Scholar
  • 11 Lerchen M L, Wiggins C L, Samet J M. Lung cancer and occupation in New Mexico.  J Natl Cancer Inst . 1987;  79 639-645
    PubMedGoogle Scholar
  • 12 Vineis P, Thomas T, Hayes R B. Proportion of lung cancers in males, due to occupation, in different areas of the USA.  Int J Cancer . 1988;  42 851-856
    PubMedGoogle Scholar
  • 13 Doll R. Mortality from lung cancer is asbestos workers.  Br J Ind Med . 1955;  12 81-86
    PubMedGoogle Scholar
  • 14 Churg A, Stevens B. Enhanced retention of asbestos fibers in the airways of human smokers.  Am J Respir Crit Care Med . 1995;  151 1409-1413
    PubMedGoogle Scholar
  • 15 Bhatia R, Lopipero P, Smith A H. Diesel exhaust exposure and lung cancer [see comments].  Epidemiology . 1998;  9 84-91
    CrossrefPubMedGoogle Scholar
  • 16 Wu X, Delclos G L, Annegers J F. A case-control study of wood dust exposure, mutagen sensitivity, and lung cancer risk.  Cancer Epidemiol Biomarkers Prev . 1995;  4 583-588
    PubMedGoogle Scholar
  • 17 Stellman S D, Demers P A, Colin D, Boffetta P. Cancer mortality and wood dust exposure among participants in the American Cancer Society Cancer Prevention Study-II (CPS-II).  Am J Ind Med . 1998;  34 229-237
    CrossrefPubMedGoogle Scholar
  • 18 Robinson C F, Petersen M, Sieber W K, Palu S, Halperin W E. Mortality of Carpenters' Union members employed in the U.S  construction or wood products industries, 1987-1990. Am J Ind Med . 1996;  30 674-694
    PubMedGoogle Scholar
  • 19 Lubin J H, Boice J DJ, Edling C. Lung cancer in radon-exposed miners and estimation of risk from indoor exposure.  J Natl Cancer Inst . 1995;  87 817-827
    PubMedGoogle Scholar
  • 20 Darby S C, Whitley E, Howe G R. Radon and cancers other than lung cancer in underground miners: A collaborative analysis of 11 studies.  J Natl Cancer Inst . 1995;  87 378-384
    PubMedGoogle Scholar
  • 21 National Council on Radiation protection and measurements. Ionizing radition exposire of the population of the United States 93 Bethesda, MD: NCRP; 1987
  • 22 Alavanja M C, Lubin J H, Mahaffey J A, Brownson R C. Residential radon exposure and risk of lung cancer in Missouri.  Am J Public Health . 1999;  89 1042-1048
    PubMedGoogle Scholar
  • 23 Pershagen G, Akerblom G, Axelson O. Residential radon exposure and lung cancer in Sweden.  N Engl J Med . 1994;  330 159-164
    CrossrefPubMedGoogle Scholar
  • 24 Clarke R, Southwood T. Risk from ionizing radiation: A commentary.  Nature . 1989;  338 197
    CrossrefPubMedGoogle Scholar
  • 25 Lubin J H, Boice J D. Estimating Rn-induced llung cancer in the United States.  Health Physics . 1989;  57 417
    PubMedGoogle Scholar
  • 26 Wu A, Fontham E, Reynolds P, Greenberg R, Buffler P. Previous lung disease and risk of lung cancer among lifetime nonsmoking women in the United States.  Am J Epidemiol . 1995;  141 1023-1032
    CrossrefPubMedGoogle Scholar
  • 27 Alavanja M, Brownson R, Boice J, Hock E. Presxisting lung disease and lung cancer in nonsmokering women.  Am J Epidemiol . 1992;  136 623-632
    PubMedGoogle Scholar
  • 28 Nilsson R. Environmental tobacco smoke and lung cancer: A reappraisal.  Ecotoxicol Environ Saf . 1996;  34 2-17
    CrossrefPubMedGoogle Scholar
  • 29 Dockery D W, Trichopoulos D. Risk of lung cancer from environmental exposures to tobacco smoke.  Cancer Causes Control . 1997;  8 333-345
    CrossrefPubMedGoogle Scholar
  • 30 Witschi H, Joad J P, Pinkerton K E. The toxicology of environmental tobacco smoke.  Annu Rev Pharmacol Toxicol . 1997;  37 29-52
    CrossrefPubMedGoogle Scholar
  • 31 Hackshaw A K. Lung cancer and passive smoking.  Stat Methods Med Res . 1998;  7 119-136
    CrossrefPubMedGoogle Scholar
  • 32 Reynolds P, Fontham E T. Passive smoking and lung cancer.  Ann Med . 1995;  27 633-640
    PubMedGoogle Scholar
  • 33 Wu A H. Exposure misclassification bias in studies of environmental tobacco smoke and lung cancer.  Environ Health Perspect . 1999;  107 873-877
    PubMedGoogle Scholar
  • 34 Wells A J. Lung cancer from passive smoking at work.  Am J Public Health . 1998;  88 1025-1029
    PubMedGoogle Scholar
  • 35 Office of Health and Environmental Assessment. Respiratory health effects of passive smoking: Lung cancer and other disorders Washington, DC: US EPA; 1992
  • 36 Brownson R, Chang J, Davis J. Passive smoking and lung cancer in nonsmoking women.  Am J Public Health . 1992;  82 1525-1530
    PubMedGoogle Scholar
  • 37 Stockwell H, Goldman A, Lyman G. Environmental tobacco smoke and lung cancer risk in nonsmoking women.  JNCI . 1992;  84 1417-1422
    PubMedGoogle Scholar
  • 38 Riboli E, Haley N J, Tredaniel J. Do the nonsmoking daughters of smokers tend to marry smokers?.  <~>Implications for epidemiological research on environmental tobacco smoke: The IARC collaborative study. Cancer Epidemiol Biomarkers Prev . 1995;  4 821-824
    PubMedGoogle Scholar
  • 39 Wang F L, Love E J, Liu N, Dai X D. Childhood and adolescent passive smoking and the risk of female lung cancer.  Int J Epidemiol . 1994;  23 223-230
    PubMedGoogle Scholar
  • 40 Koo L C, Kabat G C, Rylander R, Tominaga S, Kato I, Ho J H. Dietary and lifestyle correlates of passive smoking in Hong Kong, Japan, Sweden, and the U.S.A  Soc Sci Med . 1997;  45 159-169
    CrossrefPubMedGoogle Scholar
  • 41 Sinha R, Kulldorff M, Curtin J, Brown C C, Alavanja M C, Swanson C A. Fried, well-done red meat and risk of lung cancer in women (United States).  Cancer Causes Control . 1998;  9 621-630
    CrossrefPubMedGoogle Scholar
  • 42 Swanson C A, Brown C C, Sinha R, Kulldorff M, Brownson R C, Alavanja M C. Dietary fats and lung cancer risk among women: The Missouri Women's Health Study (United States).  Cancer Causes Control . 1997;  8 883-893
    CrossrefPubMedGoogle Scholar
  • 43 Koo L C, Mang O W, Ho J H. An ecological study of trends in cancer incidence and dietary changes in Hong Kong.  Nutr Cancer . 1997;  28 289-301
    PubMedGoogle Scholar
  • 44 Nyberg F, Agrenius V, Svartengren K, Svensson C, Pershagen G. Dietary factors and risk of lung cancer in never-smokers.  Int J Cancer . 1998;  78 430-436
    CrossrefPubMedGoogle Scholar
  • 45 Sankaranarayanan R, Varghese C, Duffy S W, Padmakumary G, Day N E, Nair M K. A case-control study of diet and lung cancer in Kerala, south India.  Int J Cancer . 1994;  58 644-649
    PubMedGoogle Scholar
  • 46 Birkett N J. Intake of fruits and vegetables in smokers.  Public Health Nutr . 1999;  2 217-222
    PubMedGoogle Scholar
  • 47 Cooper D A, Eldridge A L, Peters J C. Dietary carotenoids and lung cancer: A review of recent research.  Nutr Rev . 1999;  57 133-145
    PubMedGoogle Scholar
  • 48 Hu J, Johnson K C, Mao Y. A case-control study of diet and lung cancer in northeast China.  Int J Cancer . 1997;  71 924-931
    CrossrefPubMedGoogle Scholar
  • 49 Speizer F E, Colditz G A, Hunter D J, Rosner B, Hennekens C. Prospective study of smoking, antioxidant intake, and lung cancer in middle-aged women (USA).  Cancer Causes Control . 1999;  10 475-482
    CrossrefPubMedGoogle Scholar
  • 50 Albanes D. Beta-carotene and lung cancer: A case study.  Am J Clin Nutr . 1999;  69 1345S-1350S
    PubMedGoogle Scholar
  • 51 Albanes D, Heinonen O P, Taylor P R. Alpha-Tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: Effects of base-line characteristics and study compliance.  J Natl Cancer Inst . 1996;  88 1560-1570
    PubMedGoogle Scholar
  • 52 Ernster V L. Female lung cancer.  Annu Rev Public Health . 1996;  17 97-114
    CrossrefPubMedGoogle Scholar
  • 53 The Centers for Disease Control and Prevention. Mortality trends for selected smoking related cancers and breast cancer-United States.  Morbid Mortal Wkly Rep . 1993;  42 863-866
    PubMedGoogle Scholar
  • 54 Garfinkel L, Silverberg E. Lung cancer and smoking trends in the United States over the past 25 years.  CA Cancer J Clin . 1991;  41 137-145
    PubMedGoogle Scholar
  • 55 Satcher D, Eriksen M. The paradox of tobacco control.  JAMA . 1994;  271 627-628
    CrossrefPubMedGoogle Scholar
  • 56 Ernster V L. The epidemiology of lung cancer in women.  Ann Epidemiol . 1994;  4 102-110
    PubMedGoogle Scholar
  • 57 US Department of Health and Human Services. Reducing the health consequences of smoking: 25 Years of progress: A report of the surgeon general. 1989. Rockville, MD: US DHHS
  • 58 Hegmann K, Fraser A, Keaney R, Moser S, Nilsena D. The effect of age at smoking initiation on lung cancer risk.  Epidemiology . 1993;  4 444-448
    PubMedGoogle Scholar
  • 59 Taioli E, Wynder E L. Re: Endocrine factors and adenocarcinoma of the lung in women [letter].  J Natl Cancer Inst . 1994;  86 869-870
    CrossrefPubMedGoogle Scholar
  • 60 Wynder E L, Hoffmann D. Smoking and lung cancer: Scientific challenges and opportunities.  Cancer Res . 1994;  54 5284-5295
    PubMedGoogle Scholar
  • 61 Zang E A, Wynder E L. Differences in lung cancer risk between men and women: Examination of the evidence.  J Natl Cancer Inst . 1996;  88 183-192
    CrossrefPubMedGoogle Scholar
  • 62 Bennett W P, Hussain S P, Vahakangas K H, Khan M A, Shields P G, Harris C C. Molecular epidemiology of human cancer risk: Gene-environment interactions and p53 mutation spectrum in human lung cancer.  J Pathol . 1999;  187 8-18
    PubMedGoogle Scholar
  • 63 Lubin J, Blot W, Berrino F. Patterns of lung cancer risk according to type of cigarette smoking.  Int J Cancer . 1984;  33 569-576
    PubMedGoogle Scholar
  • 64 Lubin J, Blot W. Assessment of lung cancer risk factors by histologic category.  JNCI . 1984;  73 383-389
    PubMedGoogle Scholar
  • 65 Osaan K. Lung cancer in women: The importance of smoking, family history of cancer, and medical history of respiratory disease.  Cancer Res . 1991;  51 4893-4897
    PubMedGoogle Scholar
  • 66 Risch H, Howe G, Jain M, Holowaty E, Burch J, Miller A. Are females smokers at higher risk for lung cancer than male smokers?.  <~>A case-control analysis by histological type. Am J Epidemiol . 1993;  138 281-293
    CrossrefPubMedGoogle Scholar
  • 67 Adami H O, Persson I, Hoover R, Schairer C, Bergkvist L. Risk of cancer in women receiving hormone replacement therapy.  Int J Cancer . 1989;  44 833-839
    CrossrefPubMedGoogle Scholar
  • 68 Kure E H, Ryberg D, Hewer A. p53 mutations in lung tumours: Relationship to gender and lung DNA adduct levels.  Carcinogen . 1996;  17 2201-2205
    PubMedGoogle Scholar
  • 69 Devesa S, Shaw G, Blot W. Changing patterns of lung cancer incidence by histological type.  Cancer Epidemiol Biomark Prev . 1991;  1 29-34
    PubMedGoogle Scholar
  • 70 Dodds L, Davis S, Polissar L. A population-based study of lung cancer incidence trends by histological types of lung cancer 1974-1981.  JNCI . 1986;  77 53-56
    PubMedGoogle Scholar
  • 71 Travis W, Travis L, Devesa S. Lung Cancer.  Cancer . 1995;  75 191-202
    CrossrefPubMedGoogle Scholar
  • 72 Wingo P A, Ries L A, Giovino G A. Annual report to the nation on the status of cancer, 1973-1996, with a special section on lung cancer and tobacco smoking.  J Natl Cancer Inst . 1999;  91 675-690
    CrossrefPubMedGoogle Scholar
  • 73 Stellman S D, Muscat J E, Thompson S, Hoffmann D, Wynder E L. Risk of squamous cell carcinoma and adenocarcinoma of the lung in relation to lifetime filter cigarette smoking.  Cancer . 1997;  80 382-388
    CrossrefPubMedGoogle Scholar
  • 74 Thun M J, Lally C A, Flannery J T, Calle E E, Flanders W D, Heath C WJ. Cigarette smoking and changes in the histopathology of lung cancer.  J Natl Cancer Inst . 1997;  89 1580-1586
    CrossrefPubMedGoogle Scholar
  • 75 Wolden S L, Lamborn K R, Cleary S F, Tate D J, Donaldson S S. Second cancers following pediatric Hodgkin's disease.  J Clin Oncol . 1998;  16 536-544
    CrossrefPubMedGoogle Scholar
  • 76 Mauch P M, Kalish L A, Marcus K C. Second malignancies after treatment for laparotomy staged IA-IIIB Hodgkin's disease: Long-term analysis of risk factors and outcome.  Blood . 1996;  87 3625-3632
    PubMedGoogle Scholar
  • 77 Harvey E, Brinton L. Second cancer following cancer of the breast in Connecticut.  Natl Cancer Inst Monogr . 1985;  68 99-112
    PubMedGoogle Scholar
  • 78 Neugut A, Robinson E, Lee W, Murray T, Karwoski K, Kutcher G. Lung cancer after radiation therapy for breast cancer.  Cancer . 1993;  71 3054-3057
    PubMedGoogle Scholar
  • 79 Neugut A, Murray T, Santos J. increased risk of lung cancer after breast cancer radiation therapy in cigarette smokers.  Cancer . 1994;  73 1615-1620
    PubMedGoogle Scholar
  • 80 Ford M, Sigurdson A, Stewart S. Lung cancer after breast cancer: The role of smoking and XRT.  Cancer Epidemiol Biomark Prev . 1999;  8 198
    PubMedGoogle Scholar
  • 81 Pisani P, Parkin D M, Bray F, Ferlay J. Estimates of the worldwide mortality from 25 cancers in 1990.  Int J Cancer . 1999;  83 18-29
    PubMedGoogle Scholar
  • 82 Liu B Q, Peto R, Chen Z M. Emerging tobacco hazards in China: 1. Retrospective proportional mortality study of one million deaths.  BMJ . 1998;  317 1411-1422
    PubMedGoogle Scholar
  • 83 Pandey M, Mathew A, Nair M K. Global perspective of tobacco habits and lung cancer: A lesson for third world countries.  Eur J Cancer Prev . 1999;  8 271-279
    PubMedGoogle Scholar
  • 84 Yang G, Fan L, Tan J. Smoking in China: Findings of the 1996 National Prevalence Survey.  JAMA . 1999;  282 1247-1253
    CrossrefPubMedGoogle Scholar
  • 85 Gao Y T. Risk factors for lung cancer among nonsmokers with emphasis on lifestyle factors.  Lung Cancer . 1996;  S39-S45 (S39-S45)
    PubMedGoogle Scholar
  • 86 Kit L W. Why is lung cancer common in non-smoking women in Hong Kong from epidemiology to molecular biology?.  Chin Med J . 1997;  110 420-424
    PubMedGoogle Scholar
  • 87 Zhong L, Goldberg M S, Gao Y T, Jin F. Lung cancer and indoor air pollution arising from Chinese-style cooking among nonsmoking women living in Shanghai, China.  Epidemiology . 1999;  10 488-494
    PubMedGoogle Scholar
  • 88 Du Y X, Cha Q, Chen X W. An epidemiological study of risk factors for lung cancer in Guangzhou, China.  Lung Cancer . 1996;  S9-S37 (S9-S37)
    PubMedGoogle Scholar
  • 89 Seow A, Duffy S W, Ng T P, McGee M A, Lee H P. Lung cancer among Chinese females in Singapore 1968-1992; Time trends, dialect group differences and implications for aetiology.  Int J Epidemiol . 1998;  27 167-172
    CrossrefPubMedGoogle Scholar
  • 90 Zheng W, Blot W, Liao M. Lung Cancer and prior tuberculosis infection in Shanghai.  Br J Cancer . 1987;  56 501-505
    PubMedGoogle Scholar
  • 91 Hussain S P, Harris C C. Molecular epidemiology of human cancer.  Recent Results Cancer Res . 1998;  154 22-36
    PubMedGoogle Scholar
  • 92 Greenblatt M S, Bennett W P, Hollstein M, Harris C C. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis.  Cancer Res . 1994;  54 4855-4878
    PubMedGoogle Scholar
  • 93 Denissenko M F, Pao A, Tang M, Pfeifer G P. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.  Science . 1996;  274 430-432
    CrossrefPubMedGoogle Scholar
  • 94 Hernandez-Boussard T M, Hainaut P. A specific spectrum of p53 mutations in lung cancer from smokers: Review of mutations compiled in the IARC p53 database [published erratum appears in Environ Health Perspect 1998;106(9):A 421].  Environ Health Perspect . 1998;  106 385-391
    PubMedGoogle Scholar
  • 95 Denissenko M F, Chen J X, Tang M S, Pfeifer G P. Cytosine methylation determines hot spots of DNA damage in the human P53 gene.  Proc Natl Acad Sci U S A . 1997;  94 3893-3898
    CrossrefPubMedGoogle Scholar
  • 96 Kohno T, Yokota J. How many tumor suppressor genes are involved in human lung carcinogenesis?.  Carcinogen . 1999;  20 1403-1410
    PubMedGoogle Scholar
  • 97 Ooi W L, Elston R C, Chen V W, Bailey-Wilson J E, Rothchild H. Increased familial risk for lung cancer.  JNCI . 1986;  76 217-222
    PubMedGoogle Scholar
  • 98 Yang P, Schwartz A G, McAllister A E, Swanson G M, Aston C E. Lung cancer risk in families of nonsmoking probands: Heterogeneity by age at diagnosis [In Process Citation].  Genet Epidemiol . 1999;  17 253-273
    CrossrefPubMedGoogle Scholar
  • 99 Amos C I, Xu W, Spitz M R. Is there a genetic basis for lung cancer susceptibility?.  Recent Results Cancer Res . 1999;  151 3-12
    PubMedGoogle Scholar
  • 100 Yang P, Schwartz A G, McAllister A E, Aston C E, Swanson G M. Genetic analysis of families with nonsmoking lung cancer probands.  Genet Epidemiol . 1997;  14 181-197
    CrossrefPubMedGoogle Scholar
  • 101 Sellers T A, Chen P L, Potter J D, Bailey-Wilson J E, Rothschild H, Elston R C. Segregation analysis of smoking-associated malignancies: Evidence for Mendelian inheritance.  Am J Med Genet . 1994;  52 308-314
    CrossrefPubMedGoogle Scholar
  • 102 Bailey-Wilson J E, Sellers T A, Elston R C, Evens C C, Rothschild H. Evidence for a major gene effect in early-onset lung cancer.  J La State Med Soc . 1993;  145 157-162
    PubMedGoogle Scholar
  • 103 Auer H, Warncke K, Nowak D. Variations of p53 in cultured fibroblasts of patients with lung cancer who have a presumed genetic predisposition.  Am J Clin Oncol . 1999;  22 278-282
    CrossrefPubMedGoogle Scholar
  • 104 Tomizawa Y, Adachi J, Kohno T, Yamaguchi N, Saito R, Yokota J. Identification and characterization of families with aggregation of lung cancer.  Jpn J Clin Oncol . 1998;  28 192-195
    CrossrefPubMedGoogle Scholar
  • 105 Phillips D, Hewer A, Martin C. Correlation of DNA adduct levels in human lung with cigarette smoking.  Nature . 1988;  336 790-792
    CrossrefPubMedGoogle Scholar
  • 106 Kato S, Bowman E, Harrington A. Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo.  JNCI . 1995;  87 902-907
    PubMedGoogle Scholar
  • 107 Jyohish B ea. DNA repair profeciency: A potential marker for identification of high risk members in breast cancer families.  Can Lett . 1998;  124 9-13
    PubMedGoogle Scholar
  • 108 Sancar A. Excision repair invades the territory of mismatch repair.  Natl Gen . 1999;  21 247-249
    PubMedGoogle Scholar
  • 109 Halushka M K, Fan J B, Bentley K. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.  Natl Genet . 1999;  22 239-247
    PubMedGoogle Scholar
  • 110 Cargill M, Altshuler D, Ireland J. Characterization of single-nucleotide polymorphisms in coding regions of human genes.  Nat Genet . 1999;  22 231-238
    CrossrefPubMedGoogle Scholar
  • 111 Kawajiri K, Nakachi K, Imri K. Identification of genetics high risk individuals to lung cancer by DNA polymorphisms of the cytochrom p450 1A1 gene.  FEBS Lett . 1990;  263 131-133
    CrossrefPubMedGoogle Scholar
  • 112 Nakachi K, Imai K, Hayashi S. Genetic susceptibity to squanmous cell carincoma of the lung in relation to cigarette smoking dose.  Can Res . 1991;  51 5177-5180
    PubMedGoogle Scholar
  • 113 Taioli E, Crofts F, Trachman J. A specific African-American CYP1A1 polymorphsism is associated with adenocarcinoma of the lung.  Cancer Res . 1995;  55 472-473
    PubMedGoogle Scholar
  • 114 Shields P, Caporaso N, Falk R. Lung cancer and a CYP1A1 genetic polymorphism.  Cancer Epidemiol Biomark Prev . 1993;  2 481-485
    PubMedGoogle Scholar
  • 115 Alexandie A-K, Sundberg M, Seidgard J. Genetic susceptibility to lung cancer with special empahsis on CYP1A1 and GSTM1: A study on host genetics factors in relations to age at onset.  Pharmacogenetics . 1994;  1 20-25
    PubMedGoogle Scholar
  • 116 Hirvonen A, Husgafvel-Pursisinen K, Karjalainen A. Lack of association with susceptibility to lung cancer in a Finnish population.  Cancer Epidemiol Biomark Prev . 1992;  1 485-489
    PubMedGoogle Scholar
  • 117 Hamada G, Sugimura H, Suzuki I. The heme binding region polymorphism of cytochrome p450 1A1 (cyp1a1) rather than RsaI polymorphism of 2E1 (CYP2E1 is associated with lung cancer in Rio de Jeneiro.  Cancer Epidemiol Biomark Prev . 1995;  4 63-67
    PubMedGoogle Scholar
  • 118 Seidegard J, Pero R, Markowitz M. Isoenzyme(s) of glutathione transferase (class mu) as a marker for the suspectibity to lung cancer.  Carcinogen . 1990;  11 33-36
    PubMedGoogle Scholar
  • 119 Nazar-Stewart V, Motulsky A, Eaton D. The glotathio S-transferase mu polymorphissm as a marker for susceptibility to lung cancer.  Cancer Res . 1993;  53 2313-2318
    PubMedGoogle Scholar
  • 120 Heckbert S, Weiss N, Hornung S. Glutathion S transferase and epoxide hydrolase activity in human leukocytes in relation to risk of lung cancer and other smoking-related cancers.  JNCI . 1992;  84 2313-2318
    PubMedGoogle Scholar
  • 121 Brockmoller J, Kerb R, Drakoulis N. Genotype and phenotype of glutathion-S transferase class mu and si in lung cancer patients and controls.  Cancer Res . 1993;  53 1004-1011
    PubMedGoogle Scholar
  • 122 Ryberg D, Skaug V, Hewer S. Genotype of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk.  Carcinogen . 1997;  18 329-333
    PubMedGoogle Scholar
  • 123 Camus A, Geneste O, Honakoski P. High variability of nitrosamine metabolism amoung individuals: Role of cytochromes p450 2d6 and 2e1 in the dealkylation of n-nitroodimethylamine and N-nitrosodietylamine in mice and humans.  Mol Carcinog . 1993;  7 275
    PubMedGoogle Scholar
  • 124 Shaw G L. Genetic polymorphism of CYP2D6 and lung cancer risk.  Cancer Epidemiol Biomark Prev . 1998;  7 215-219
    PubMedGoogle Scholar
  • 125 Wu X, Shi H, Jinag H. Association between cytochrome P4502E1 genotype, mutagen sensitivity, cigarette smoking, and susceptibility to lung cancer.  Carcinogen . 1997;  18 967-973
    PubMedGoogle Scholar
  • 126 Wu X, Amos C I, Kemp B L. Cytochrome P450 2E1 DraI polymophisms in lung cancer in minority populations.  Cancer Epidemiol Biomark Prev . 1998;  7 13-18
    PubMedGoogle Scholar
  • 127 Spitz M R, Wei Q, Li G, Wu X. Genetic susceptibility to tobacco carcinogenesis.  Cancer Invest . 1999;  17 645-659
    PubMedGoogle Scholar
  • 128 Wei Q, Cheng L, Hong W K, Spitz M R. Reduced DNA repair capacity in lung cancer patients.  Cancer Res . 1996;  56 4103-4107
    PubMedGoogle Scholar
  • 129 Cheng L, Eicher S A, Guo Z, Hong W K, Spitz M R, Wei Q. Reduced DNA repair capatcity in head and neck cancer patients.  Cancer Epidemiol Biomark Prev . 1998;  7 465-468
    PubMedGoogle Scholar
  • 130 Spitz M R, Wei Q, Li G, Wu X. Genetic susceptibility to tobacco carcinogenesis [In Process Citation].  Cancer Invest . 1999;  17 645-659
    PubMedGoogle Scholar
  • 131 Spitz M R, Hsu T C. Mutagen sensitivity as a marker of cancer risk.  Cancer Detect Prev . 1994;  18 299-303
    PubMedGoogle Scholar
  • 132 Spitz M R, Hsu T C, Wu X, Fueger J J, Amos C I, Roth J A. Mutagen sensitivity as a biological marker of lung cancer risk in African Americans.  Cancer Epidemiol Biomark Prev . 1995;  4 99-103
    PubMedGoogle Scholar
  • 133 Wiencke J K, Spitz M R, McMillan A, Kelsey K T. Lung cancer in Mexican-Americans and African-Americans is associated with the wild-type genotype of the NAD(P)H: Quinone oxidoreductase polymorphism.  Cancer Epidemiol Biomark Prev . 1997;  6 87-92
    PubMedGoogle Scholar
  • 134 Spitz M R, Lippman S M, Jiang H. Mutagen sensitivity as a predictor of tumor recurrence in patients with cancer of the upper aerodigenstive tract.  JNCI . 1998;  90 243-245
    CrossrefPubMedGoogle Scholar
  • 135 Spitz M R, Hoque A, Trizna Z. Mutagen sensitivity as a risk factor for second malignant tumors following malignancies of the upper aerodigestive tract.  J Natl Cancer Inst . 1994;  86 1681-1684
    PubMedGoogle Scholar
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