Synthesis of Polyamines, Their Derivatives, Analogues and Conjugates

Vladimir Kuksa; Robert Buchan; Paul Kong Thoo Lin

doi:10.1055/s-2000-6405

Synthesis 2000; 2000(9): 1189-1207
DOI: 10.1055/s-2000-6405

review

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Synthesis of Polyamines, Their Derivatives, Analogues and Conjugates

Vladimir Kuksa^* , Robert Buchan, Paul Kong Thoo Lin

^*The Robert Gordon University, School of Applied Sciences, St. Andrew Street, Aberdeen, AB25 1HG, Scotland, UK; Fax + 44(12 24)26 28 28; E-mail: p.kong@rgu.ac.uk

Abstract

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The role of polyamines in biological systems is now well recognised. In this review an introduction to polyamines and their biological significance is first outlined. The main focus of this review is on the chemical strategies used in the synthesis of polyamines, their derivatives, analogues and conjugates. Recent developments in solid phase synthesis of more complex polyamine molecules is also covered.

polyamines - analogues - conjugates - synthesis - methodology

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