Selective Deprotection of Silyl Ethers

Todd D. Nelson; R. David Crouch

doi:10.1055/s-1996-4350

Synthesis 1996; 1996(9): 1031-1069
DOI: 10.1055/s-1996-4350

review

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Selective Deprotection of Silyl Ethers

Todd D. Nelson¹ , R. David Crouch²

¹Merck Research Laboratories, Department of Process Chemistry, P.O. Box 2000, 80Y-140, Rahway, New Jersey 07065-9000, USA, Fax +1(908)5946703; E-mail todd_nelson@merck.com
²Dickinson College, Department of Chemistry, Carlisle, Pennsylvania 17013, USA, E-mail: crouch@dickinson.edu

Abstract

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This review focuses on the selective deprotection of silyl ethers in the presence of other like or unlike silyl ethers. Various examples are highlighted throughout the text, and these examples are compiled in tabular form at the end of the document (Tables 16-27). The abbreviations and structures for some of the more common silyl groups are given in Figure 1.

desilylations - deprotection - protecting groups - silyl ether

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