Esophageal intramural Pseudodiverticulosis in a Patient with Amyloidosis and Recurrent Esophageal Candidiasis: A Case Report

A 57-year-old woman with a history of amyloidosis with renal involvement and long-standing asthma, who has required treatment with inhaled corticosteroids over the past few years. Due to this, she has experienced multiple episodes of oral and esophageal candidiasis, requiring several treatment cycles with fluconazole and nystatin.

The patient developed new-onset, progressive dysphagia to solids, which led to a 5% loss of body weight, prompting a decision to perform a gastroscopy. The procedure revealed pseudodiverticular-like mucosa throughout the esophagus, with multiple small ostium-like openings, without alterations in the interdiverticular esophageal mucosa or signs of stenosis [1] [2].

Biopsies were taken, showing esophageal mucosa with nonspecific lymphocytic infiltration, no eosinophils, and basal cell spongiosis.

Esophageal intramural pseudodiverticulosis is a rare and benign condition characterized by small protrusions in the esophageal wall, corresponding to dilations of the esophageal submucosal glands. Various conditions are associated with the development of pseudodiverticulosis, including esophageal candidiasis, gastroesophageal reflux disease, esophagitis, diabetes mellitus, and alcohol use. The most common symptom is intermittent or progressive dysphagia, related to stenosis or secondary esophageal motility disorders. Some cases of clinical improvement have been described following treatment of the underlying cause of the pseudodiverticulosis.

Publication History

Article published online:
27 March 2025

• References

• 1 Alameri A, Sharman T.. Esophageal Intramural Pseudodiverticulosis. 2023 Jan 30. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024
• 2 Shintaku M.. Esophageal intramural pseudodiverticulosis. World J Gastroenterol 2024; 30 (2): 137-145