Endoscopy 2025; 57(S 02): S221
DOI: 10.1055/s-0045-1805543
Abstracts | ESGE Days 2025
Moderated poster
EUS guided tissue acquisition: Needles and techniques 04/04/2025, 10:00 – 11:00 Poster Dome 1 (P0)

Preliminary Results of Macroscopic On-Site Evaluation in Pancreatic Lesions: A Prospective Multicenter Study

H Delsa
1   Cheikh Khalifa International University Hospital, Mohammed VI University of Sciences and Health, Casablanca, Morocco
2   Gastroenterology, Mohammed VI University of Sciences and Health, Casablanca, Morocco
,
E Ghoneem
3   Gastroenterology and Hepatology, Internal Medicine Department, Mansoura University, Mansoura, Egypt
,
H Hiwa
4   Sulaimani Center for Advanced Gastrointestinal Endoscopy, Sulaymaniy, Iraq
,
K Ragab
5   Gastroenterology, Theodor Bilharz Research Institute, cairo, Egypt
,
O Abdallah
6   Mansoura University, Mansoura, Egypt
,
R Fedoua
7   Mohamed V Military training hospital, Rabat, Morocco
,
M Borahma
8   Department of Gastroenterology C, Hospital Ibn Sina, Rabat, Morocco
,
F Ghalim
9   Digestive Endoscopy Unit, Mekka Clinic, Casablanca, Morocco
,
M Farouk
10   Department of Tropical Medicine and Gastroenterology, Luxor University, Luxor, Egypt
,
M Lasheen
5   Gastroenterology, Theodor Bilharz Research Institute, cairo, Egypt
,
M Elbasiony
6   Mansoura University, Mansoura, Egypt
,
A Elsayed Alzamzamy
11   Military Medical Academy, Cairo, Egypt
,
A El Deeb
12   National Hepatology and Tropical Medicine Research Institute, cairo, Egypt
,
H Atalla
6   Mansoura University, Mansoura, Egypt
,
M El-Ansary
5   Gastroenterology, Theodor Bilharz Research Institute, cairo, Egypt
,
S Mohamed
12   National Hepatology and Tropical Medicine Research Institute, cairo, Egypt
,
M Elshair
13   Faculty of Medicine, Al-Azhar University, cairo, Egypt
,
W Khannoussi
2   Gastroenterology, Mohammed VI University of Sciences and Health, Casablanca, Morocco
,
M Abu-Amer
13   Faculty of Medicine, Al-Azhar University, cairo, Egypt
,
A Elmekkaoui
14   CHU HASSAN II FES, Fes, Morocco
,
M Sherif Naguib
15   Department of Gastroenterology, Ahmed Maher Teaching Hospital, Cairo, Egypt
,
A E adil
16   MOHAMMED VI UNIVERISTY HOSPITAL, Marrakech, Morocco
,
A El-Meligui
17   Kasr Al-Aini School of Medicine, Cairo University, cairo, Egypt
,
A El-Habashi
18   Department of Pathology, National Cancer Institute, Cairo University, cairo, Egypt
,
M Gamal Ameen
19   Oncological Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
,
I Benelbardhadi
2   Gastroenterology, Mohammed VI University of Sciences and Health, Casablanca, Morocco
,
D Abdelfatah
20   Department of Cancer Epidemiology and Biostatistics, National Cancer Institute, Cairo University, cairo, Egypt
,
M Kaddah
21   Department of Endemic Medicine Faculty of Medicine, Cairo University, cairo, Egypt
,
H H Okasha
22   Internal Medicine Department, Division of Gastroenterology, Kasr Al-Aini School of Medicine, Cairo, Egypt
› Author Affiliations
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Aims The aim of our study is to evaluate the performance of macroscopic on-site evaluation (MOSE) during endoscopic ultrasound-guided fine needle aspiration/biopsy (EUS-FNA/FNB) for pancreatic lesions.

Methods Over one year, we conducted a multicentic prospective study across 16 centers in three countries (Egypt, Iraq, and Morocco), involving 1008 patients referred for endoscopic ultrasound (EUS). We analyzed their MOSE of EUS-FNA/FNB using two different classifications to assess the adequacy of histological core samples. A total of 664 patients with pancreatic lesions were included in the study. Data management and analysis were performed using the Statistical Package for the Social Sciences (SPSS) version 27.

Results In 664 patients with pancreatic lesions, a total of 707 lesions were biopsied. Of the patients, 344 (51.8%) were male, and the mean age was 60 years. The average lesion size was 39 mm. The most commonly used needles were FNB-Franseen (73.6%) and 22 G (93.4%), with a median of 2 passes. Based on two classifications, 618 non-bloody cores (61.3%) and 964 adequate samples (95.6%) were considered suitable for histological evaluation. The overall diagnostic yield of cytopathology was 95.5%, with cytology confirming malignancy in 861 patients (85.4%) and 45 specimens (4.5%) being inconclusive. Post-procedural adverse events were reported in 33 patients (3.3%). Statistical analysis demonstrated the high sensitivity of FNB and a correlation between the MOSE score and the final diagnosis.

Conclusions Pancreatic lesions are challenging to biopsy, but good MOSE cores predict high accuracy. Our study confirmed the higher sensitivity of FNB and the increased diagnostic yield of cytopathology with good MOSE scores.



Publication History

Article published online:
27 March 2025

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