Pharmacopsychiatry 2024; 57(02): 93
DOI: 10.1055/s-0044-1779581
Abstracts │ XVth Symposium of the Task Force Therapeutic Drug Monitoring of the AGNP
Poster Abstracts

Serum Levels of Methylphenidate and Efficacy Measures in Children With Attention-Deficit/Hyperactivity Disorder After Crossover Intake of Ritalin​ LA and Medikinet​ retard in a Classroom Setting.

Authors

  • Ü. Yagcioglu

    1   Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg,, Freiburg, Germany

  • K. Schneider-Momm

    1   Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg,, Freiburg, Germany

  • J. Kempf

    2   Institute of Forensic Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Germany

  • S. S. Hagenkötter

    1   Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg,, Freiburg, Germany

  • R. Rauh

    1   Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg,, Freiburg, Germany

  • H.W. Clement

    1   Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg,, Freiburg, Germany

  • E. Schulz

    1   Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg,, Freiburg, Germany

  • M. Biscaldi

    1   Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg,, Freiburg, Germany

  • C. Fleischhaker

    1   Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg,, Freiburg, Germany
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Aim of this study was to determine the serum levels of methylphenidate and efficacy measures after intake of Ritalin​ LA and Medikinet​ retard. Patients with attention-deficit/hyperactivity disorder (ADHD) were assigned in a laboratory classroom-setting.

24 boys, aged 8 to 14 years took part in this single blind, randomized, two-period crossover study. All patients were diagnosed with ADHD according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Ritalin​ LA 20 mg and Medikinet​ retard 20 mg were given for 7 days each, the classroom setting was on day 7. The Swanson, Kotlin, Agler, M-Flynn, and Pelham (SKAMP) scale and math tests were used to determine the drug’s efficacy. Liquid chromatography-mass spectrometry (LC-MS/MS) was performed to measure serum levels of MPH. Blood samples were taken at ten different times on each classroom day. Efficacy parameters were assessed at seven times each classroom day.

The complete determination of the pharmacokinetic parameters could be performed for 20 patients. The mean Cmax serum MPH concentration for Ritalin​ LA was 18.3 ± 8.7 ng/ml compared to Medikinet​ retard 22.6 ± 9.3 ng/ml. The mean AUC (0 – 8 h) serum MPH value for Ritalin LA was 93.1 ± 57.2 ng/ml/h compared to Medikinet retard 111.4 ± 45.8 ng/ml/h. MPH concentrations have formed two distinctive peak levels. In a cross-over analysis, the SKAMP Scales showed no significant treatment effects. For both medications, no serious adverse events could be observed.

An analogue classroom setting provides a reliable parallel assessment of behavioral and pharmacokinetic data. Pharmacokinetic data showed remarkable inter-individual variations. In both medication groups, the pharmacokinetic profiles have revealed two distinctive peak levels in some patients.



Publication History

Article published online:
12 March 2024

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