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Pharmacopsychiatry 2019; 52(02): 84-91
DOI: 10.1055/s-0044-100523
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Prescription of Benzodiazepines and Related Drugs in Patients with Mild Cognitive Deficits and Alzheimer’s Disease

Philipp Hessmann
1   Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Germany
2   Center for Health Economics Research Hannover (CHERH), Leibniz University Hannover, Germany
,
Richard Dodel
3   Department of Neurology, Philipps-University Marburg, Germany
4   University Hospital Essen, Geriatric Centre Haus Berge, Contilia GmbH, Germany
,
Erika Baum
5   Department of General Practice, Philipps-University Marburg, Germany
,
Matthias J. Müller
6   Oberberg Clinics Berlin, Germany, and Faculty of Medicine, Justus-Liebig-University Giessen, Germany
,
Greta Paschke
7   Practice for General Medicine, Wiesbaden, Germany
,
Bernhard Kis
1   Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Germany
,
Jan Zeidler
2   Center for Health Economics Research Hannover (CHERH), Leibniz University Hannover, Germany
,
Mike Klora
2   Center for Health Economics Research Hannover (CHERH), Leibniz University Hannover, Germany
,
Jens-Peter Reese
8   Coordinating Center for Clinical Trials, Philipps-University Marburg, Germany
,
Monika Balzer-Geldsetzer
3   Department of Neurology, Philipps-University Marburg, Germany
4   University Hospital Essen, Geriatric Centre Haus Berge, Contilia GmbH, Germany
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Weitere Informationen

Publikationsverlauf

received 13. November 2017
revised  17. Dezember 2017

accepted  03. Januar 2018

Publikationsdatum:
31. Januar 2018 (online)

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Abstract

Introduction Benzodiazepines and related drugs (BZDR) should be avoided in patients with cognitive impairment. We evaluated the relationship between a BZDR treatment and the health status of patients with Alzheimer’s disease (AD).

Methods Cross-sectional study in 395 AD patients using bivariate and multiple logistic analyses to assess correlations between the prescription of BZDR and patients’ characteristics (cognitive and functional capacity, health-related quality of life (HrQoL), neuropsychiatric symptoms).

Results BZDR were used in 12.4% (n=49) of all participants. In bivariate analyses, the prescription was associated with a lower HrQoL, a higher need of care, and the presence of anxiety. Multivariate models revealed a higher risk of BZDR treatment in patients with depression (OR 3.85, 95% CI: 1.45 – 10.27). Community-dwelling participants and those treated by neurologists/psychiatrists had a lower risk of receiving BZDR (OR 0.33, 95% CI: 0.12 – 0.89 and OR 0.16, 95% CI: 0.07 – 0.36).

Discussion The inappropriate use of BZDR conflicts with national and international guidelines. We suggest evaluating indications and treatment duration and improving the knowledge of alternative therapies in healthcare institutions.

Key words

benzodiazepines - dementia - depression - neuropsychiatric specialists
 

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