Rhodium(III)-Catalyzed C–C Bond Formation by Direct C–H Activation

Xiaolan Li; Haiqing Luo

doi:10.1055/s-0043-1775442

Synlett, Inhaltsverzeichnis

Synlett 2025; 36(08): 985-992
DOI: 10.1055/s-0043-1775442

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Rhodium(III)-Catalyzed C–C Bond Formation by Direct C–H Activation

Xiaolan Li

^aDepartment of Chemistry & Chemical Engineering, Gannan Normal University, Ganzhou 341000, P. R. of China

^bCollege of Chemistry, Nanchang University, Nanchang, Jiangxi 330031, P. R. of China

,

Haiqing Luo∗

^aDepartment of Chemistry & Chemical Engineering, Gannan Normal University, Ganzhou 341000, P. R. of China

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Abstract

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Abstract

Transition-metal-catalyzed functionalizations of C–H bonds to construct C–C bonds represent an ideal route in the synthesis of valuable organic molecules. In particular, rhodium(III)-catalyzed C–H bond activation offers an attractive strategy due to its efficiency and step economy for direct functionalization in organic synthesis. Consequently, recent developments in this area have assured a high level of regioselectivity in C–H functionalization reactions. In this Account, we have summarized our recent achievements in the functionalizations of sp²- and sp³-C–H bonds using rhodium catalyst. The scope, limitation, and mechanism of these reactions have been described briefly.

1 Introduction

2 C–H Arylation

2.1 Aromatic C(sp²)–H Arylation

2.2 Benzylic C(sp³)–H Arylation

2.3 Olefinic C(sp²)–H Arylation

3 Olefinic C(sp²)–H Alkenylation and Alkylation

4 Olefinic C(sp²)–H Heteroarylation

5 Conclusion

Key words

rhodium(III)-catalyzed - C–H activation - arylation - alkenylation - alkylation - heteroarylation

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