Pharmacopsychiatry 2019; 52(01): 16-23
DOI: 10.1055/s-0043-125392
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Fat Mass and Obesity-Related Gene Variants rs9939609 and rs7185735 are Associated with Second-Generation Antipsychotic-Induced Weight Gain

Charlotte Schröder
1  Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technischen Universität München, München, Germany
,
Fabian Czerwensky
1  Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technischen Universität München, München, Germany
,
Stefan Leucht
2  Klinik für Psychiatrie und Psychotherapie, Klinikum rechts der Isar, Technischen Universität München, München, Germany
,
Werner Steimer
1  Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technischen Universität München, München, Germany
› Author Affiliations
Further Information

Publication History

received 28 June 2017
revised 12 December 2017

accepted 19 December 2017

Publication Date:
15 January 2018 (eFirst)

Abstract

Introduction Weight gain is a limiting and frequent adverse effect of second-generation antipsychotic therapy. Identifying genetic risk factors would significantly improve pharmacotherapy.

Methods We focused on rs7185735 and rs9939609, 2 common single nucleotide polymorphisms of the fat mass and obesity-associated (FTO) gene reported to be associated with obesity. Three-hundred fifty Caucasian inpatients were included in a naturalistic study.

Results After 4 weeks of treatment, we did not observe any significant association of polymorphisms with weight change in the whole study population (p>0.05). In a subpopulation without additional weight-inducing comedication (n=178), G-allele carriers of rs7185735 gained 3.4 times more weight (1.69 kg±3.1 kg, p=0.019) than AA genotypes (0.49 kg±3.1 kg). A-allele carriers of rs9939609 gained 3.1 times more weight (1.65 kg±3.1 kg, p=0.029) than TT genotypes (0.54 kg±3.2 kg).

Discussion Our findings confirm the role of the FTO gene as a high-potential risk factor for obesity and indicate a value for predicting a weight gain induced by second-generation antipsychotics. Further, we detected an additive effect of FTO rs7185735 and MC4R rs17782313.

Supporting Information