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Horm Metab Res 2018; 50(03): 179-192
DOI: 10.1055/s-0043-123763
Review
© Georg Thieme Verlag KG Stuttgart · New York

MicroRNAs and Target Genes in Pituitary Adenomas

Yajuan Feng   *
1   Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China
,
Zhi-gang Mao   *
2   Department of Neurosurgery and Pituitary Tumor Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China
,
Xin Wang
1   Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China
,
Qiu Du
1   Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China
,
Mengyao Jian
1   Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China
,
Dimin Zhu
2   Department of Neurosurgery and Pituitary Tumor Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China
,
Zheng Xiao
2   Department of Neurosurgery and Pituitary Tumor Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China
,
Hai-jun Wang
2   Department of Neurosurgery and Pituitary Tumor Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China
,
Yong-hong Zhu
1   Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China
› Author Affiliations
Further Information

Publication History

received 06 September 2017

accepted 15 November 2017

Publication Date:
19 January 2018 (online)

Also available at
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Abstract

Pituitary adenomas account for the top three primary intracranial tumors in terms of total incidence rates. The clinical symptoms presented by the disease are often characterized by a series of systemic endocrine disorders, severe occupational lesions, and even some malignant features, and therefore early diagnosis and predicting recurrence would be instructive for clinical treatment of pituitary adenomas. An increasing number of specific microRNA (miRNA) expression signatures have been identified in pituitary, and miRNAs are related with the pituitary tumorigenesis, dysfunction, neurodegeneration, and metastatic non-functioning pituitary carcinoma. Here, this paper reviews the effects of aberrant miRNA expression in human pituitary adenomas and summarizes some corresponding target genes and biological significance over the last 7 years (2010–2017).

Key words

miRNA - pituitary adenoma - pituitary gland - target genes

* These authors contributed equally to this work


 

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