Exp Clin Endocrinol Diabetes 2018; 126(05): 316-320
DOI: 10.1055/s-0043-120110
Article
© Georg Thieme Verlag KG Stuttgart · New York

Evaluation of the Relation Between Omentin-1 and Vitamin D in Postmenopausal Women With or Without Osteoporosis

Okan Dikker
1   Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
3   Department of Medical Biochemistry, Okmeydani Training and Research Hospital, Okmeydani, Istanbul, Turkey
,
Seldag Bekpinar
1   Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
,
Gul Ozdemirler
2   Department of Medical Biochemistry,Faculty of Medicine, Halic University, Sutluce Istanbul, Turkey
,
Mujdat Uysal
1   Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
,
Muberra Vardar
3   Department of Medical Biochemistry, Okmeydani Training and Research Hospital, Okmeydani, Istanbul, Turkey
,
Sevgi Atar
4   Department of Physical Therapy and Rehabilitation, Okmeydani Training and Research Hospital, Okmeydani, Istanbul, Turkey
,
Murat Usta
5   Department of Medical Biochemistry, Giresun University, Faculty of Medicine, Nizamiye Giresun, Turkey
,
Berrin Huner
4   Department of Physical Therapy and Rehabilitation, Okmeydani Training and Research Hospital, Okmeydani, Istanbul, Turkey
› Author Affiliations
Further Information

Publication History

received 01 June 2017
first decision 14 September 2017

accepted 21 September 2017

Publication Date:
08 November 2017 (online)

Abstract

Introduction Crosstalk between bone and adipose tissues is implicated in several pathologic conditions related to bone metabolism. Omentin-1, a 34-kD protein, is released from omental adipose tissue. A few studies indicated the effect of omentin-1 on bone health and bone mineral density (BMD) and the interaction of omentin-1 with vitamin D. Therefore, this study aimed to investigate the relationship between omentin-1, vitamin D, and BMD in postmenopausal women with osteoporosis compared with non-osteoporotic counterparts.

Materials and methods Forty postmenopausal women with osteoporosis (OP), 40 counterparts without OP, and 30 premenopausal women were enrolled. Dual-energy X-ray Absorptiometry results, body mass index, and some demographic and biochemical data were recorded. Vitamin D (25-hydroxyvitamin D3) levels were measured using liquid chromatography-tandem mass spectrometry. Serum omentin-1 was determined using an enzyme-linked immunosorbent assay.

Results Omentin-1 levels tended to increase in both postmenopausal women groups compared with the control group, but this increase was significant only in women with osteoporosis. Vitamin D levels were not different between the groups. When women were categorized according to vitamin D levels, women with normal vitamin D levels had significantly higher omentin-1 levels. A positive correlation was found between omentin-1 and vitamin D levels in all groups (r=0.197, p=0.041, n=110).

Conclusion The tendency to an increase in omentin-1 levels in postmenopausal women with osteoporosis may be due to a physiologic compensation against bone loss after menopause. The linear relationship between omentin-1 and vitamin D suggests that adipose tissue is one of the target tissues for the vitamin D effect.