TumorDiagnostik & Therapie, Inhaltsverzeichnis TumorDiagnostik & Therapie 2017; 38(09): 562-565DOI: 10.1055/s-0043-119229 Schwerpunkt Prostatakarzinom © Georg Thieme Verlag KG Stuttgart · New YorkMehr als klassische Androgendeprivation: Neue operative und medikamentöse Therapieoptionen, beim fortgeschrittenen Prostatakarzinom Markus T. Grabbert , David Pfister , Axel HeidenreichArtikel empfehlen Abstract Artikel einzeln kaufen Etwa 13 000 Männer versterben jährlich in Deutschland an einem Prostatakarzinom und die Therapieoptionen beim lokal fortgeschrittenen und metastasierten Prostatakarzinom werden ständig weiterentwickelt. Dieser Beitrag fasst die aktuellen chirurgischen und medikamentösen Optionen zusammen. Volltext Referenzen Literatur 1 Robert Koch-Institut. http://www.krebsdaten.de/Krebs/DE/Content/Krebsarten/Prostatakrebs/prostatakrebs_node.html (Zugriff: 27.07.2017) 2 Cornford P, Bellmunt J, Bolla M. et al. EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part II: Treatment of Relapsing, Metastatic, and Castration-Resistant Prostate Cancer. Europ Urol 2017; 71: 630-642 3 Sweeney CJ, Chen YH, Carducci M. et al. Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer. New Engl J Med 2015; 373: 737-746 4 Fizazi K, Tran N, Fein L. et al. Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer. New Engl J Med 2017; 377: 352-360 5 Tannock IF, de Wit R, Berry WR. et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. New Engl J Med 2004; 351: 1502-1512 6 de Bono JS, Logothetis CJ, Molina A. et al. Abiraterone and increased survival in metastatic prostate cancer. New Engl J Med 2011; 364: 1995-2005 7 Shore ND, Chowdhury S, Villers A. et al. Efficacy and safety of enzalutamide versus bicalutamide for patients with metastatic prostate cancer (TERRAIN): a randomised, double-blind, phase 2 study. Lancet Oncol 2016; 17: 153-163 8 Siemens DR, Klotz L, Heidenreich A. et al. Efficacy and Safety of Enzalutamide vs Bicalutamide in Younger and Older Patients with Metastatic Castration-resistant Prostate Cancer in the TERRAIN Trial. J Urol 2017 in press 9 Litwin MS, Tan HJ. The Diagnosis and Treatment of Prostate Cancer: A Review. JAMA 2017; 317: 2532-2542 10 Scher HI, Fizazi K, Saad F. et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. New Engl J Med 2012; 367: 1187-1197 11 Maughan BL, Luber B, Nadal R. et al. Comparing Sequencing of Abiraterone and Enzalutamide in Men With Metastatic Castration-Resistant Prostate Cancer: A Retrospective Study. Prostate 2017; 77: 33-40 12 Parker C, Nilsson S, Heinrich D. et al. Alpha emitter radium-223 and survival in metastatic prostate cancer. New Engl J Med 2013; 369: 213-223 13 Kretschmer A, Herlemann A, Stief CG. et al. When is surgical treatment indicated in metastatic prostate cancer and what is the scientific rationale?. Urologe A 2017; 56: 599-603 14 Heidenreich A, Varga Z, Von Knobloch R. Extended pelvic lymphadenectomy in patients undergoing radical prostatectomy: high incidence of lymph node metastasis. J Urol 2002; 167: 1681-1686 15 Engel J, Bastian PJ, Baur H. et al. Survival benefit of radical prostatectomy in lymph node-positive patients with prostate cancer. Europ Urol 2010; 57: 754-761 16 Gakis G, Boorjian SA, Briganti A. et al. The role of radical prostatectomy and lymph node dissection in lymph node-positive prostate cancer: a systematic review of the literature. European urology 2014; 66: 191-199 17 Mandel P, Rosenbaum C, Pompe RS. et al. Long-term oncological outcomes in patients with limited nodal disease undergoing radical prostatectomy and pelvic lymph node dissection without adjuvant treatment. World J Urol 2017 in press 18 Heidenreich A, Moul JW, Shariat S. et al. Role of salvage lymph node dissection in prostate cancer. Curr Opin Urol 2016; 26: 581-589 19 Horn T, Zahel T, Adt N. et al. Evaluation of Computed Tomografy for Lymph Node Staging in Bladder Cancer Prior to Radical Cystectomy. Urologia internat 2016; 96: 51-56 20 Spek A, Herlemann A, Gratzke C. et al. Radical prostatectomy as part of a multimodal concept for patients with prostate cancer and bone metastases at initial diagnosis. Urologe A 2017; 56: 595-598 21 Heidenreich A, Briganti A, Shariat S. et al. MP53-19 Cytoreductive radical prostatectomy (CRP) is feasible in men with hormone-naïve, metastatic prostate cancer (MPCA). J Urol 2017 in press 22 Rexer H. Metastatic, hormone-naive prostate cancer interventional study: Multicenter, prospective, randomized study to evaluate the effect of standard drug therapy with or without radical prostatectomy in patients with limited bone metastasized prostate cancer (G-RAMPP – the AUO AP 75/13 study). Urologe A 2015; 54: 1613-1616 23 Heidenreich A. Palliative Radical (Cysto-) prostatectomy for Locally Advanced, Symptomatic Castration-resistant Prostate Cancer. Europ Urol Foc 2016; 2: 478-479