Planta Med 2018; 84(04): 221-224
DOI: 10.1055/s-0043-117838
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Effects of Cannabidiol on Morphine Conditioned Place Preference in Mice

James Roland Markos
1  Department of Psychology, University of Mississippi, University, MS, USA
,
Hannah M. Harris
1  Department of Psychology, University of Mississippi, University, MS, USA
,
Waseem Gul
2  Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS, USA
4  ElSohly Laboratories Inc., Oxford, MS, USA
,
Mahmoud A. ElSohly
2  Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS, USA
3  Department of BioMolecular Science, University of Mississippi, University, MS, USA
4  ElSohly Laboratories Inc., Oxford, MS, USA
,
Kenneth J. Sufka
1  Department of Psychology, University of Mississippi, University, MS, USA
2  Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS, USA
› Author Affiliations
Further Information

Publication History

received 19 April 2017
revised 11 July 2017

accepted 25 July 2017

Publication Date:
09 August 2017 (online)

Abstract

This study sought to determine whether the cannabis constituent cannabidiol attenuates the development of morphine reward in the conditioned place preference paradigm. Separate groups of mice received either saline or morphine in combination with one of four doses of cannabidiol using three sets of drug/no-drug conditioning trials. After drug-place conditioning, morphine mice displayed robust place preference that was attenuated by 10 mg/kg cannabidiol. Further, when administered alone, this dose of cannabidiol was void of rewarding and aversive properties. The finding that cannabidiol blocks opioid reward suggests that this compound may be useful in addiction treatment settings.