Exp Clin Endocrinol Diabetes
DOI: 10.1055/s-0043-115904
© Georg Thieme Verlag KG Stuttgart · New York

Effect of a 12-Week Aerobic Exercise Training on Serum Fetuin-A and Adipocytokine Levels in Type 2 Diabetes

Ling-Yun Zhang1, Tao Liu2, Ya-Qin Teng1, Xiao-Yan Yao1, Tian-Tian Zhao1, Liang-Yan Lin1, Qing-Song Jin1, Yong-Jun Jin1
  • 1Department of Endocrinology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China
  • 2Teaching and Research Office of Military Sport, Naval Aeronautical and Astronautical University, Yantai, Shandong, China
Further Information

Publication History

received 02 April 2017
revised 06 July 2017

accepted 06 July 2017

Publication Date:
27 July 2017 (eFirst)


Objective We aimed to evaluate the effect of 12-week aerobic exercise training on fetuin-A levels in type 2 diabetes mellitus and examine the relationships between fetuin-A and adipocytokine levels and cardiovascular risk factors.

Methods The study included 32 patients with type 2 diabetes mellitus who were assigned to an exercise or a control group. The exercise group underwent 12 weeks of exercise (consisting of a 5-min warm-up, 60-min aerobic bicycle training performed at 70% of the maximal heart rate, a cool-down period, 5 times/week). Adiponectin, resistin, and fetuin-A serum levels were measured using enzyme-linked immunosorbent assay. Leptin serum levels were measured by a radioimmunoassay.

Results Exercise for 12 weeks significantly reduced serum fetuin-A (643.1±109.4 to 448.7±92.5 μg/mL, P<0.05), leptin (11.9±7.2 to 8.6±5.7 ng/dL, P<0.05), and resistin (3.2±1.5 to 2.2±1.4 ng/mL, P<0.05) levels, but increased adiponectin (6.9±1.9 to 8.1±1.7 µg/mL, P<0.05) levels. In the exercise group, Δfetuin-A positively correlated with differences in weight (r=0.654, P=0.046), body mass index (r=0.725, P=0.002), waist circumference (r=0.898, P=0.013), and adiponectin levels (r=0.662, P=0.035).

Conclusions Aerobic exercise significantly decreased serum fetuin-A levels in type 2 diabetes mellitus, which can be attributed to weight loss and related to increased adiponectin levels.