Exp Clin Endocrinol Diabetes
DOI: 10.1055/s-0043-115904
Article
© Georg Thieme Verlag KG Stuttgart · New York

Effect of a 12-Week Aerobic Exercise Training on Serum Fetuin-A and Adipocytokine Levels in Type 2 Diabetes

Ling-Yun Zhang
Department of Endocrinology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China
,
Tao Liu
Teaching and Research Office of Military Sport, Naval Aeronautical and Astronautical University, Yantai, Shandong, China
,
Ya-Qin Teng
Department of Endocrinology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China
,
Xiao-Yan Yao
Department of Endocrinology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China
,
Tian-Tian Zhao
Department of Endocrinology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China
,
Liang-Yan Lin
Department of Endocrinology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China
,
Qing-Song Jin
Department of Endocrinology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China
,
Yong-Jun Jin
Department of Endocrinology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China
› Author Affiliations
Further Information

Publication History

received 02 April 2017
revised 06 July 2017

accepted 06 July 2017

Publication Date:
27 July 2017 (eFirst)

Abstract

Objective We aimed to evaluate the effect of 12-week aerobic exercise training on fetuin-A levels in type 2 diabetes mellitus and examine the relationships between fetuin-A and adipocytokine levels and cardiovascular risk factors.

Methods The study included 32 patients with type 2 diabetes mellitus who were assigned to an exercise or a control group. The exercise group underwent 12 weeks of exercise (consisting of a 5-min warm-up, 60-min aerobic bicycle training performed at 70% of the maximal heart rate, a cool-down period, 5 times/week). Adiponectin, resistin, and fetuin-A serum levels were measured using enzyme-linked immunosorbent assay. Leptin serum levels were measured by a radioimmunoassay.

Results Exercise for 12 weeks significantly reduced serum fetuin-A (643.1±109.4 to 448.7±92.5 μg/mL, P<0.05), leptin (11.9±7.2 to 8.6±5.7 ng/dL, P<0.05), and resistin (3.2±1.5 to 2.2±1.4 ng/mL, P<0.05) levels, but increased adiponectin (6.9±1.9 to 8.1±1.7 µg/mL, P<0.05) levels. In the exercise group, Δfetuin-A positively correlated with differences in weight (r=0.654, P=0.046), body mass index (r=0.725, P=0.002), waist circumference (r=0.898, P=0.013), and adiponectin levels (r=0.662, P=0.035).

Conclusions Aerobic exercise significantly decreased serum fetuin-A levels in type 2 diabetes mellitus, which can be attributed to weight loss and related to increased adiponectin levels.