Effect of a 12-Week Aerobic Exercise Training on Serum Fetuin-A and Adipocytokine Levels in Type 2 Diabetes
received 02 April 2017
revised 06 July 2017
accepted 06 July 2017
27 July 2017 (eFirst)
Objective We aimed to evaluate the effect of 12-week aerobic exercise training on fetuin-A levels in type 2 diabetes mellitus and examine the relationships between fetuin-A and adipocytokine levels and cardiovascular risk factors.
Methods The study included 32 patients with type 2 diabetes mellitus who were assigned to an exercise or a control group. The exercise group underwent 12 weeks of exercise (consisting of a 5-min warm-up, 60-min aerobic bicycle training performed at 70% of the maximal heart rate, a cool-down period, 5 times/week). Adiponectin, resistin, and fetuin-A serum levels were measured using enzyme-linked immunosorbent assay. Leptin serum levels were measured by a radioimmunoassay.
Results Exercise for 12 weeks significantly reduced serum fetuin-A (643.1±109.4 to 448.7±92.5 μg/mL, P<0.05), leptin (11.9±7.2 to 8.6±5.7 ng/dL, P<0.05), and resistin (3.2±1.5 to 2.2±1.4 ng/mL, P<0.05) levels, but increased adiponectin (6.9±1.9 to 8.1±1.7 µg/mL, P<0.05) levels. In the exercise group, Δfetuin-A positively correlated with differences in weight (r=0.654, P=0.046), body mass index (r=0.725, P=0.002), waist circumference (r=0.898, P=0.013), and adiponectin levels (r=0.662, P=0.035).
Conclusions Aerobic exercise significantly decreased serum fetuin-A levels in type 2 diabetes mellitus, which can be attributed to weight loss and related to increased adiponectin levels.
- 1 Nangami GN, Watson K, Parker-Johnson K. et al. Fetuin-A (alpha2HSglycoprotein) is a serum chemo-attractant that also promotes invasion of tumor cells through Matrigel. Biochem Biophys Res Commun 2013; 438: 660-665
- 2 Swallow CJ, Partridge EA, Macmillan JC. et al. α2HS-glycoprotein,an antagonist of transforming growth factor- ß in vivo, inhibits intestinal tumor progression. Cancer Res 2004; 64: 6402-6409
- 3 Szweras M, Liu D, Partridge EA. et al. α2-HS glycoprotein/Fetuin, a transforming growth factor ß/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling. J Biol Chem 2002; 277: 19991-19997
- 4 Barclay L, Vega C.. Fetuin - A linked with incident diabetes. J Am Med Assoc 2008; 300: 182-188
- 5 Brix JM, Stingl H, Höllerl F. et al. Elevated Fetuin-A concentrations in morbid obesity decrease after dramatic weight loss. J Clin Endocrinol Metab 2010; 95: 4877-4881
- 6 Ix JH, Shlipak MG, Brandenburg VM. et al. Association between human fetuin-A and the metabolic syndrome data from the heart and soul study. Circulation 2006; 113: 1760-1767
- 7 Ix JH, Wassel CL, Kanaya AM. et al. Fetuin-A and incident diabetes mellitus in older persons. JAMA 2008; 300: 182-188
- 8 Ou HY, Yang YC, Wu HT. et al. Increased fetuin-A concentrations in impaired glucose tolerance with or without nonalcoholic fatty liver disease, but not impaired fasting glucose. J Clin Endocrinol Metab 2012; 97: 4717-4723
- 9 Stefan N, Fritsche A, Weikert C. et al. Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes 2008; 57: 2762-2767
- 10 Siddiq A, Lepretre F, Hercberg S. et al. A synonymous coding polymorphism in theα2-HeremansSchmid glycoprotein gene is associated with type-2 diabetes in French Caucasians. Diabetes 2005; 54: 2477-2481
- 11 Sun Q, Cornelis MC, Manson JE. et al. Plasma levels of fetuin-A and hepatic enzymes and risk of type 2 diabetes in women in the US. Diabetes 2013; 62: 49-55
- 12 Jensen MK, Bartz TM, Mukamal KJ. et al. Fetuin-A, type 2 diabetes, and risk of cardiovascular disease in older adults: the Cardiovascular Health study. Diabetes Care 2013; 36: 1222-1228
- 13 Laughlin GA, Cummins KM, Wassel CL. et al. The association of fetuin-A with cardiovascular disease mortality in older community-dwelling adults: The Rancho Bernardo study. J Am Coll Cardiol 2012; 59: 1688-1696
- 14 Siegel-Axel DI, Ullrich S, Stefan N. et al. Fetuin-A influences vascular cell growth and production of proinflmmatory and angiogenic proteins by human perivascular fat cells. Diabetologia 2014; 57: 1057-1066
- 15 Malin SK, Del Rincon JP, Huang H. et al. Exercise-induced lowering of fetuin-A may increase hepatic insulin sensitivity. Med Sci Sports Exerc 2014; 46: 2085-2090
- 16 Schultes B, Frick J, Ernst B. et al. The effect of 6-weeks of aerobic exercise training on serum fetuin-A levels in non-diabetic obese women. Exp Clin Endocrinol Diabetes 2010; 118: 754-756
- 17 Yang SJ, Hong HC, Choi HY. et al. Effects of a three-month combined exercise programme on fibroblast growth factor 21 and fetuin-A levels and arterial stiffness in obese women. Clin Endocrinol (Oxf) 2011; 75: 464-469
- 18 Malin SK, Mulya A, Fealy CE. et al. Fetuin-A is linked to improved glucose tolerance after short-term exercise training in nonalcoholic fatty liver disease. J Appl Physiol 2013; 115: 988-994
- 19 Matthews DR, Hosker JP, Rudenski AS. et al. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419
- 20 Choi KM, Han KA, Ahn HJ. et al. The effects of caloric restriction on fetuin-A and cardiovascular risk factors in rats and humans: a randomized controlled trial. Clin Endocrinol (Oxf) 2013; 79: 356-363
- 21 Haukeland JW, Dahl TB, Yndestad A. et al. Fetuin A in nonalcoholic fatty liver disease: In vivo and in vitro studies. Eur J Endocrinol 2012; 166: 503-510
- 22 Reinehr T, Roth CL.. Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss. J Clin Endocrinol Metab 2008; 93: 4479-4485
- 23 Lakka TA, Laaksonen DE.. Physical activity in prevention and treatment of the metabolic syndrome. Applied Physiology, Nutrition, and Metabolism 2007; 32: 76-88
- 24 Mokhtarzade M, Ranjbar R, Majdinasab N. et al. Effect of aerobic interval training on serum IL-10, TNFα, and adipokines levels in women with multiple sclerosis: Possible relations with fatigue and quality of life. Endocrine 2017; DOI: 10.1007/s12020-017-1337-y.
- 25 Miller EG, Sethi P, Nowson CA. et al. Effects of progressive resistance training and weight loss versus weight loss alone on inflammatory and endothelial biomarkers in older adults with type 2 diabetes. Eur J Appl Physiol 2017; DOI: 10.1007/s00421-017-3657-2.
- 26 Hennige AM, Staiger H, Wickert C. et al. Fetuin-A induces cytokine expression and suppresses adiponectin production. PLoS One 2008; 3: e1765
- 27 Stefan N, Fritsche A, Weikert C. et al. Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes 2008; 57: 2762-2767
- 28 You T, Arsenis NC, Disanzo BL. et al. Effects of exercise training on chronic inflammation in obesity: Current evidence and potential mechanisms. Sports Med 2013; 43: 243-256
- 29 Iwabu M, Yamauchi T, Okada-Iwabu M. et al. Adiponectin and AdipoR1 regulate PGC-1alpha and miochondria by Ca(2+) and AMPK/SIRT1. Nature 2010; 464: 1313-1319
- 30 Ix JH, Sharma K.. Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: The roles of fetuin-A, adiponectin, and AMPK. J Am Soc Nephrol 2010; 21: 406-412
- 31 Kelly KR, Blaszczak A, Haus JM. et al. A 7-d exercise program increases high-molecular weight adiponectin in obese adults. Med Sci Sports Exerc 2012; 44: 69-74
- 32 Jung TW, Young BS, Choi HY. et al. Salsalate and adiponectin ameliorate hepatic steatosis by inhibition of the hepatokinefetuin-A. Biochem Pharmacol 2013; 86: 960-969
- 33 Jenkins NT, McKenzie JA, Hagberg JM. et al. Plasma fetuin-A concentrations in young and older high- and low-active men. Metabolism 2011; 60: 265-271