Klin Monbl Augenheilkd 2018; 235(11): 1269-1277
DOI: 10.1055/s-0043-115902
Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Operieren wir die Glaukome zu spät?

Do We Perform Glaucoma Surgery too Late?
Jörg Peter Egon Stürmer
1   Augenklinik, Kantonsspital Winterthur, Schweiz
,
Christoph Faschinger
2   Univ.-Augenklinik, Medizinische Universität Graz, Österreich
› Author Affiliations
Further Information

Publication History

eingereicht 18 April 2017

akzeptiert 28 June 2017

Publication Date:
24 August 2017 (online)

Zusammenfassung

Aus der Sicht des operativen Glaukomatologen fragt man sich, warum die Patienten erst sehr spät zur Operation zugewiesen werden. Meist besteht schon zur Zeit der Zuweisung zur filtrierenden Operation nach vielen Jahren der konventionellen Therapie ein sowohl funktionell als auch morphologisch fortgeschrittener Glaukomschaden, zusätzlich ist auch oft noch der Augeninnendruck unter einer lokalen Maximaltherapie dekompensiert. Zusätzlich kommt hinzu, dass die Patienten oft ein fortgeschrittenes Alter aufweisen und schon viele Jahre lang mit verschiedenen Kombinationen aus Tropfen therapiert wurden. Sehr spät gestellte Diagnosen stellen eher die Ausnahme dar. Die Gründe für diese späte Zuweisung sind vielfältig. Neben der immer besseren (besser verträglichen und wirksamen) medikamentösen Glaukomtherapie spielen die Abneigung der Patienten gegen den operativen Eingriff (da keine Verbesserung des Sehvermögens zu erwarten ist) und die bis jetzt (noch) nicht verfügbare optimale Glaukomoperation eine entscheidende Rolle. Anhand einer kleinen retrospektiven Studie der letzten 274 zur filtrierenden Glaukomoperation zugewiesenen Patienten sollen die Kriterien für eine rechtzeitige Indikationsstellung erarbeitet und kritisch analysiert werden. In dieser Studie zeigt sich, dass rund ¾ aller Glaukompatienten spät oder zu spät zur Glaukomoperation zugewiesen werden. Für den niedergelassenen Ophthalmologen ohne Spezialisierung im Glaukombereich werden Kriterien formuliert, wann ein Patient zur Glaukomoperation zugewiesen werden sollte. Diese Kriterien sind grundsätzlich für alle Glaukomoperationen anzuwenden. Die Vor- und Nachteile einer filtrierenden Glaukomoperation werden jedoch besonders hervorgehoben, da dieser Eingriff nach wie vor den Goldstandard darstellt. Da aber die Trabekulektomie leider kein optimaler Glaukomeingriff ist, bestehen berechtigte Hoffnungen, dass die moderneren, weniger invasiven und damit auch weniger risikobehafteten Glaukomeingriffe (MIGS) die Indikationen für einen drucksenkenden Eingriff erweitern und damit die Hemmschwelle für die Zuweisung zur Glaukomoperation herabsetzen.

Abstract

As glaucoma specialists, we often ask ourselves why patients are referred so late for surgery. Usually the patient is referred in a far advanced stage of the disease after long-term conventional treatment with topical medications. By that time, substantial morphologic damage is present and the patient is disabled by far advanced visual field defects. In addition, decompensated intraocular pressure, despite maximal tolerated medical treatment, is seen. Delayed surgery due to late diagnosis is rather a rare event. Various reasons may be responsible for this late referral. Improved IOP-lowering medications (i.e., fixed combinations), personal aversion (fear and knowledge of lack of improvement in visual acuity) against surgery, and imperfect glaucoma procedures may play an important role. A retrospective review of the last 274 cases referred for filtering glaucoma surgery is used to describe and analyze criteria for adequate timing of glaucoma surgery. This study reveals that almost ¾ of patients are referred rather late for glaucoma surgery. Criteria for adequate timing of glaucoma surgery are given for non-glaucoma specialists in particular. They apply for all types of glaucoma surgery, and the pros and cons are discussed in detail. Trabeculectomy is still regarded as the gold standard of glaucoma surgery. Because trabeculectomy may not be an ideal glaucoma procedure, there is hope that the modern less-invasive glaucoma procedures (MIGS) will be able to extend indications for glaucoma surgery. This may also lower the hurdle of referral for glaucoma surgery for both patients and non-glaucoma specialist doctors.

 
  • Literatur

  • 1 Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol 2006; 90: 262-267
  • 2 Katz LJ, Steinmann WC, Kabir A. et al. Selective laser trabeculoplasty versus medical therapy as initial treatment of glaucoma: a prospective randomized trial. J Glaucoma 2002; 21: 460-468
  • 3 Waisbourd M, Katz LJ. Selective laser-trabeculoplasty as first-line therapy: a review. Can J Ophthalmology 2014; 49: 519-522
  • 4 Li X, Wang W, Zhang X. Meta-analysis of selective laser-trabeculoplasty versus topical medication in the treatment of open-angle glaucoma. BMC Ophthalmol 2015; 15: 107
  • 5 Miki A, Kawashima R, Usui S. et al. Treatment outcomes and prognostic factors of selective laser trabeculoplasty for open-angle glaucoma receiving maximal-tolerable medical therapy. J Glaucoma 2016; 25: 785-789
  • 6 Polat J, Grantham L, Mitchell K, Realini T. Repeatability of selective laser trabeculoplasty. Br J Ophthalmol 2016; 100: 1437-1441
  • 7 Cairns JE. Trabeculectomy. Preliminary report of a new method. Am J Ophthalmol 1968; 66: 673-679
  • 8 Terminology and Guidelines for Glaucoma 4th Edition (2014). Im Internet: http://www.eugs.org/eng/egs_guidelines_reg.asp Stand: 04.08.2017
  • 9 Chauhan BC, Garway-Heath DF, Goni FJ. et al. Practical recommendations for measuring rates of visual field change in glaucoma. Br J Ophthalmol 2008; 92: 569-573
  • 10 Medeiros FA, Zangwill LM, Bowd C. et al. The structure and function relationship in glaucoma: implications for detection of progression and measurement of rates of change. Invest Ophthalmol Vis Sci 2012; 53: 6939-6946
  • 11 Medeiros FA, Lisboa R, Weinreb RN. et al. Retinal ganglion cell count estimates associated with early development of visual field defects in glaucoma. Ophthalmology 2013; 120: 736-744
  • 12 Rulli E, Biagioli E, Riva I. et al. Efficacy and safety of trabeculectomy vs. nonpenetrating surgical procedures. a systematic review and meta-analysis. JAMA Ophthalmol 2013; 131: 1573-1582
  • 13 Matlach J, Klinik T. Trabekulektomie versus Kanaloplastik. Ophthalmologe 2015; 112: 325-331
  • 14 Sawchyn AK, Slabaugh MA. Innovations and adaptations in trabeculectomy. Curr Opin Ophthalmol 2016; 27: 158-163
  • 15 Papadopoulos M, Khaw PT. Improving glaucoma filtering surgery. Eye (Lond) 2011; 15: 131-132
  • 16 Wells AP, Bunce C, Khaw PT. Flap suture manipulation after trabeculectomy with adjustable sutures: titration of flow and intraocular pressure in guarded filtration surgery. J Glaucoma 2004; 13: 400-406
  • 17 Dhingra S, Khaw PT. The Moorfields safer surgery system. Middle East Afr J Ophthalmol 2009; 16: 112-115
  • 18 Stalmans I, Gillis A, Lafaut AS. et al. Safe trabeculectomy technique: long term outcome. Br J Ophthalmol 2006; 90: 44-47
  • 19 Gale J, Wells AP. Medium-term outcomes of safe surgery system trabeculectomies. Br J Ophthalmol 2008; 92: 1232-1235
  • 20 Jampel HD, Musch DC, Gillespie BW. et al. Perioperative complications of trabeculectomy in the Collaborative Initial Glaucoma Treatment Study (CIGTS). Am J Ophthalmol 2005; 140: 16-22
  • 21 Kirwan JF, Lockwood AJ, Shah P. et al. Trabeculectomy in the 21st century. A multicenter analysis. Ophthalmology 2013; 120: 2532-2539
  • 22 Lichter PR, Musch DC, Gillespie BW. et al. Interim clinical outcomes in The Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery. Ophthalmology 2001; 108: 1943-1953
  • 23 Jampel HD, Solus JF, Tracey PA. et al. Outcomes and bleb-related complications of trabeculectomy. Ophthalmology 2012; 119: 712-722
  • 24 Zahid S, Musch DC, Niziol LM. et al. Risk of endophthalmitis and other long-term complications of trabeculectomy in the Collaborative Initial Glaucoma Teatment Study (CIGTS). Am J Ophthalmol 2013; 155: 674-680
  • 25 Saeedi OJ, Jefferys JL, Solus JF. et al. Risk factors for adverse consequences on low intraocular pressure after trabeculectomy. J Glaucoma 2014; 23: e60-e68
  • 26 CAT-152 0102 Trabeculectomy Study Group. Khaw P, Grehn F. et al. A phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. Ophthalmology 2007; 114: 1822-1830
  • 27 Stürmer J, Mermoud A, Sunaric Mégevand G. Erste Erfahrungen mit einem retikulierten Hyaluronsäurepräparat bei der Trabekulektomie. Klin Monatsbl Augenheilkd 2010; 227: 273-276
  • 28 Cillino S, Casuccio A, Di Pace F. et al. Biodegradable collagen matrix implant versus mitomycin-C in trabeculectomy: five-year follow-up. BMC Ophthalmol 2016; 16: 24
  • 29 Perez CI, Mellado F, Jones A. et al. Trabeculectomy combined with collagen matrix implant (Ologen). J Glaucoma 2017; 26: 54-58
  • 30 Van Bergen T, Vandewalle E, Moons L. et al. Complementary effects of bevacicumab and MMC in the improvement of surgical outcome after glaucoma filtration surgery. Acta Ophthalmol 2015; 93: 667-678
  • 31 Janz NK, Wren PA, Musch DC. et al. The Collaborative Initial Glaucoma Treatment Study: interim quality of life findings after initial medical or surgical treatment of glaucoma. Ophthalmology 2001; 108: 1954-1965
  • 32 Quaranta L, Riva I, Gerardi C. et al. Quality of life in glaucoma: a review of the literature. Adv Ther 2016; 33: 959-981
  • 33 Marquardt D, Lieb WE, Grehn F. Intensified postoperative care versus conventional follow-up: a retrospective long-term analysis of 177 trabeculectomies. Graefes Arch Clin Exp Ophthalmol 2004; 242: 106-113
  • 34 Budenz DL, Hoffman K, Zacchei A. Glaucoma filtering bleb dysesthesia. Am J Ophthalmol 2001; 131: 626-630
  • 35 Barton K. Bleb dysesthesia. J Glaucoma 2003; 12: 281-284
  • 36 Leung EW, Medeiros FA, Weinreb RN. Prevalence of ocular surface disease in glaucoma patients. J Glaucoma 2008; 17: 350-355
  • 37 Guedes RA, Guedes VM, Freitas SM. et al. Quality of life of medically versus surgically treated glaucoma patients. J Glaucoma 2013; 22: 369-373
  • 38 Gupta D, Musch DC, Niziol LM. et al. Refusal of trabeculectomy for the fellow eye in Collaborative Initial Glaucoma Treatment Study (CIGTS) participants. Am J Ophthalmol 2016; 166: 1-7
  • 39 Peponis VG, Chalkiadakis SE, Katzakis MC. et al. The effect of phacoemulsification on late bleb failure or intraocular pressure in patients with glaucoma: a systematic review. Clin Ophthalmol 2012; 6: 1045-1049
  • 40 Longo A, Uva MG, Reibaldi A. et al. Long-term effect of phacoemulsification on trabeculectomy function. Eye (Lond) 2015; 29: 1347-1352
  • 41 Salaga-Pylak M, Kowal M, Zarnowski T. Deterioration of filtering bleb morphology and function after phacoemulsification. BMC Ophthalmol 2013; 13: 17
  • 42 Nguyen DQ, Niyadurupola N, Tapp RJ. et al. Effect of phacoemulsification on trabeculectomy function. Clin Exp Ophtalmol 2014; 42: 433-439
  • 43 Klinik J, Schmitz B, Lieb WE. et al. Filtering bleb function after clear cornea phacoemulsification: a prospective study. Br J Ophthalmol 2015; 89: 597-601
  • 44 Patel HY, Danesh-Meyer HV. Incidence and management of cataract after glaucoma surgery. Curr Opin Ophthalmol 2013; 24: 15-20
  • 45 Shahid H, Salmon JF. Use of 5-Flurouracil injections to reduce the risk of trabeculectomy bleb failure after cataract surgery. J Ocul Pharmacol Ther 2010; 26: 119-123
  • 46 Augustinus CJ, Zeyen T. The effect of phacoemulsification and combined phaco/glaucoma procedures on the intraocular pressure in open-angle glaucoma: a review of the literature. Bull Soc Belge Ophtalmol 2012; 320: 51-66
  • 47 Jin GJ, Crandall AS, Jones JJ. Phacotrabeculectomy: assessment of outcomes and surgical improvements. J Cataract Refract Surg 2007; 33: 1201-1208
  • 48 Khandelwal RR, Raje D, Rathi A. et al. Surgical outcome of safe surgery system trabeculectomy combined with cataract extraction. Eye (Lond) 2015; 29: 363-370
  • 49 Chen PP, Lin SC, Junk AK. et al. The effect of phacoemulsification on intraocular pressure in glaucoma patients. A report by the American Academy of Ophthalmology. Ophthalmology 2015; 122: 1294-1307
  • 50 Shrivastava A, Singh K. The impact of cataract surgery on glaucoma care. Curr Opin Ophthalmol 2014; 25: 19-25
  • 51 Thomas R, Walland M, Thomas A. et al. Lowering of intraocular pressure after phacoemulsification in primary open-angle and angle-closure glaucoma: a Bayesian analysis. Asia Pac J Ophthalmol (Phila) 2016; 5: 79-84
  • 52 Iancu R, Corbu C. Intraocular pressure after phacoemulsification in patients with uncontrolled primary open angle glaucoma. J Med Life 2014; 7: 11-16
  • 53 Takihara Y, Inatani M, Ogata-Iwao M. et al. Trabeculectomy for open-angle glaucoma in phakic eyes vs. pseudophakic eyes after phacoemulsification. A prospective clinical cohort study. JAMA Ophthalmol 2014; 132: 69-76
  • 54 Gedde SJ, Schiffman JC, Feuer WJ. et al. Treatment outcomes in the Tube versus Trabeculectomy Study after five years of follow-up. Am J Ophthalmol 2012; 153: 789-803
  • 55 McMillan BD, Gross RL. Trabeculectomy first in pseudophakic eyes requiring surgery for medically-uncontrolled glaucoma. Surv Ophthalmol 2017; 62: 104-108
  • 56 Gedde SJ, Kornmann HL. Glaucoma surgery in pseudophakic eyes: tube shunt first. Surv Ophthalmol 2017; 62: 108-112
  • 57 Chen G, Li W, Jiang F. et al. Ex-PRESS implantation versus trabeculectomy in open-angle glaucoma: a meta-analysis of randomized controlled clinical trials. PLoS One 2014; 9: e86045
  • 58 Arora KS, Robin AL, Corcoran KJ. et al. Use of various glaucoma surgeries and procedures in medicare beneficiaries from 1994 to 2012. Ophthalmology 2015; 122: 1615-1624
  • 59 Vinod K, Gedde SJ. Clinical investigation of new glaucoma procedures. Curr Opin Ophthalmol 2017; 28: 187-193
  • 60 Kerr NM, Wang J, Barton K. Minimally invasive glaucoma surgery as primary stand-alone surgery for glaucoma. Clin Exp Ophthalmol 2017; 45: 393-400
  • 61 Gedde SJ, Herndon LW, Brandt JD. et al. Postoperative complications in the Tube Versus Trabeculectomy (TVT) Study during five years of follow-up. Am J Ophthalmol 2012; 153: 804-814
  • 62 Rosentreter A, Strzalkowski P, Bula AM. et al. Glaukomdrainageimplantate und ihre Bedeutung: Tube-versus-Trabekulektomie-Studie. Klin Monatsbl Augenheilkd 2017; DOI: 10.1055/s-0042-120278.
  • 63 Villamarin A, Stergiopulos N, Bigler S. et al. In vivo testing of a novel adjustable glaucoma drainage device. Invest Ophthalmol Vis Sci 2014; 55: 7520-7524
  • 64 DʼAlessandro E, Guidotti JM, Mansouri K. et al. XEN-augmented Baerveldt: a new surgical technique for refractory glaucoma. J Glaucoma 2017; 26: e90-e92
  • 65 Broadway DC, Grierson I, OʼBrian C. et al. Adverse effects of topical antiglaucoma medication: II. The outcome of filtration surgery. Arch Ophthalmol 1994; 112: 1446-1454
  • 66 Boimer C, Birt CM. Preservative exposure and surgical outcomes in glaucoma patients: The PESO study. J Glaucoma 2013; 22: 730-735
  • 67 Caprioli J, de Leon JM, Azarbod P. et al. Trabeculectomy can improve long-term visual function in glaucoma. Ophthalmology 2016; 123: 117-128
  • 68 Baril C, Vianna JR, Shuba LM. et al. Rates of glaucomatous visual field change after trabeculectomy. Br J Ophthalmol 2017; 101: 874-878
  • 69 Lee EJ, Kim TW, Weinreb RN. Reversal of lamina cribrosa displacement and thickness after trabeculectomy in glaucoma. Ophthalmology 2012; 119: 1359-1366
  • 70 Reis AS, OʼLeary NO, Stanfield MJ. et al. Laminar displacement and prelaminar tissue thickness change after glaucoma surgery imaged with optical coherence tomography. Invest Ophthamol Vis Sci 2012; 53: 5819-5826
  • 71 Lee EJ, Kim TW. Lamina cribrosa reversal after trabeculectomy and the rate of progressive retinal nerve fiber layer thinning. Ophthalmology 2015; 122: 2234-2242