Klin Padiatr 2022; 234(05): 343-344
DOI: 10.1055/s-0042-1754512
Abstracts
Poster
Poster Walk 4: CF

Respiratory microbiota profiles in episodes with and without respiratory symptoms in infants with CF

Authors

  • R Steinberg

    1   Inselspital, Bern Unviersity Hospital, University of Bern, Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Bern, Switzerland

  • I Korten

    1   Inselspital, Bern Unviersity Hospital, University of Bern, Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Bern, Switzerland

  • M Hilty

    2   University of Bern, Department for Infectious Diseases (IFIK), Bern, Switzerland

  • P Latzin

    1   Inselspital, Bern Unviersity Hospital, University of Bern, Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Bern, Switzerland

  • K Ramsey

    1   Inselspital, Bern Unviersity Hospital, University of Bern, Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Bern, Switzerland
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Introduction Respiratory tract infections (RTI) are a driving force for pulmonary exacerbations and lung function decline in people with cystic fibrosis (CF). It has become clear that the respiratory microbiota is closely related to the pathogenesis of RTIs. While several studies could show these associations in healthy infants, data in infants with CF is scarce. Aim of the study was the investigation of the respiratory microbiota in CF and healthy infants in episodes with and without respiratory symptoms.

Methods We analyzed the microbiota in biweekly nasal samples in 50 infants with CF and 30 healthy controls from two prospective birth cohorts followed throughout the first year of life. We assessed respiratory symptoms at time of sample via standardized telephone interviews.

Results We analyzed 1557 data points (963 in CF). The respiratory microbiota differed between CF and healthy infants: relative abundance of Staphylococcaceae was higher (Coef 0.19; 95% CI 0.02 – 0.35; p = 0.024) and of Moraxellaceae was lower (Coef -0.29; 95% CI -0.42 – -0.15; p <0.001) in the CF group. During RTIs healthy infants had an increased abundance of Streptococcaceae (Coef 0.26, 95% CI 0.01 – 0.51; p = 0.038), whereas CF infants had a lower abundance of Staphylococcaceae (Coef-0.2; 95% CI -0.4 – -0.01; p = 0.038).

Conclusion We could confirm results of previous studies with differences in microbiota composition between healthy and CF infants. Furthermore, we found a different microbiota composition during RTIs – changes differed between CF and healthy infants. We explain the lower abundance of Streptococcaceae in CF infants during respiratory symptoms as a consequence of antibiotic treatment in the CF group. In a next step, we will now investigate in-depth microbiota profiles to be able to better understand the association of infections and antibiotic treatment with the microbiota in early CF disease.



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Artikel online veröffentlicht:
21. September 2022

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