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CC BY 4.0 · SynOpen 2022; 06(04): 258-262
DOI: 10.1055/s-0042-1751375
paper

A Practical and Economical Route to (S)-Glycidyl Pivalate

Jeffrey M. Noble 
a   Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100, USA
,
Le Chang
b   WuXi AppTec (Wuhan) Co. Ltd., Wuhan East Lake High-tech Development Zone, Wuhan 430075, P. R. of China
,
Dan Chen
b   WuXi AppTec (Wuhan) Co. Ltd., Wuhan East Lake High-tech Development Zone, Wuhan 430075, P. R. of China
,
Binglin Wang
b   WuXi AppTec (Wuhan) Co. Ltd., Wuhan East Lake High-tech Development Zone, Wuhan 430075, P. R. of China
,
Raymond N. Dominey
c   Department of Chemistry, Gottwald Center for the Sciences, University of Richmond, VA 23173, USA
,
Daniel W. Cook
a   Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100, USA
,
Justina M. Burns
a   Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100, USA
,
Rodger W. Stringham
a   Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100, USA
,
Flavio S. P. Cardoso  ∗
a   Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100, USA
,
David R. Snead  ∗
a   Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100, USA
› Author AffiliationsWe thank the Bill and Melinda Gates Foundation for continuous support of our research.
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Abstract

An efficient method to prepare enantiopure (S)-glycidyl pivalate from (R)-epichlorohydrin and pivalic acid is reported. This work provides an alternative to the synthesis of this important building block from readily available and inexpensive materials.

Key words

tuberculosis - API - pretomanid - epichlorohydrin - supply centered synthesis

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/s-0042-1751375.
  • Supporting Information


Publication History

Received: 25 August 2022

Accepted after revision: 15 September 2022

Article published online:
19 October 2022

© 2022. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)

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