PDF herunterladen
Am J Perinatol 2024; 41(09): 1269-1274
DOI: 10.1055/s-0042-1749630
Original Article

Oxygen Saturation Profiles in Healthy Term Infants in Early Postnatal Life

Elizabeth M. Goetz
1   Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin
,
Brandon D. Tomlin
2   Department of Pediatrics, University of Utah, Salt Lake City, Utah
,
Kathryn E. Rinaldo
1   Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin
,
Nicole L. Baumann-Blackmore
1   Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin
,
Rachel L. Petro
1   Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin
,
Beth B. Smith
1   Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin
,
Jasmine Y. Zapata
1   Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin
,
Michael R. Lasarev
3   Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin
,
Elizabeth B. McBride 
1   Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin
,
Dinushan C. Kaluarachchi 
1   Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin
› Institutsangaben Funding This study was supported by the UnityPoint Meriter Foundation.
› Weitere Informationen
Auch verfügbar auf
    Lizenzen und Reprints

Abstract

Objective Oxygen saturation profiles generated by pulse oximetry are used as a clinical tool in the neonatal intensive care unit (NICU). There is limited evidence on normal oxygen saturation profile values in term infants. This study aimed to determine oxygen saturation profiles over an 8-hour monitoring period among healthy term neonates between 24 and 48 hours after birth.

Study Design A prospective cohort study of healthy term neonates born at 37 to 41 weeks of gestation. Preductal oxygen saturations were continuously monitored for an 8-hour period between 24 and 48 hours of life using pulse oximetry. Oxygen profile histograms were recorded for analysis. The average percent oxygen saturation (SpO2) was measured over the entire study duration for each neonate and was characterized as the fraction of time of their SpO2 reading was in each of five intervals: ≤80, 81 to 84, 85 to 89, 90 to 94, and 95 to 100%.

Results Seventy-five neonates were included in the study. Median SpO2 was 95.4%. Percentage time spent in each of the five SpO2 intervals was as follows: 0.07 (≤80), 0.15 (81–84), 0.88 (85–89), 26.9 (90–94), and 67.3% (95–100%). Eighteen infants (24%) spent the highest percentage of time in SpO2 of 90 to 94%.

Conclusion This study provides reference ranges for oxygen profiles in healthy term neonates during 24 to 48 hours of life. Nearly one-quarter of newborns spent the highest percentage of time in SpO2 of 90 to 94%. This data is important when interpreting oxygen saturation profiles of term neonates admitted to the NICU.

Key Points

  • This study provide reference ranges for oxygen profiles in healthy term neonates during 24 to 48 hours.

  • Median SpO2 was 95.4%.

  • Nearly one quarter of newborns spent the highest percentage of time in SpO2 of 90 to 94%.

Keywords

oxygen saturation - histogram - term newborns - saturation profiles


Publikationsverlauf

Eingereicht: 04. Dezember 2021

Angenommen: 28. März 2022

Artikel online veröffentlicht:
10. Juli 2022

© 2022. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

  • References

  • 1 Sur A, Paria A. Histogram analysis for bedside respiratory monitoring in not critically ill preterm neonates: a proposal for a new way to look at the monitoring data. Eur J Pediatr 2021; 180 (01) 283-289
    CrossrefPubMedSuche in Google Scholar
  • 2 Gentle S, El-Ferzli G, Winter L, Salas AA, Philips Iii JB. Oxygen saturation histogram monitoring to reduce death or retinopathy of prematurity: a quality improvement initiative. J Perinatol 2020; 40 (01) 163-169
    CrossrefPubMedSuche in Google Scholar
  • 3 Gentle SJ, Ambalavanan N, Carlo WA. Oxygen saturation histograms predict nasal continuous positive airway pressure-weaning success in preterm infants. Pediatr Res 2020; 88 (04) 637-641
    CrossrefPubMedSuche in Google Scholar
  • 4 Mascoll-Robertson KK, Viscardi RM, Woo HC. The objective use of pulse oximetry to predict respiratory support transition in preterm infants: an observational pilot study. Respir Care 2016; 61 (04) 416-422
    CrossrefPubMedSuche in Google Scholar
  • 5 Niaz S, Kumar V, Rahim A, Khan A, Bham A, Ali SR. Variation in oxygen saturation by pulse oximetry during and after breastfeeding among healthy term neonates during early postnatal life at tertiary care hospital. Cureus 2021; 13 (07) e16564
    PubMedSuche in Google Scholar
  • 6 Shah PS, Hakak H, Mohamed A, Shah J, Young J, Kelly E. Oxygen saturation profile in late-preterm and term infants: a prospective cohort study. J Perinatol 2014; 34 (12) 917-920
    CrossrefPubMedSuche in Google Scholar
  • 7 Rath C, Kluckow M. Oxygen saturation profile of term equivalent extreme preterm infants at discharge - comparison with healthy term counterparts. Acta Paediatr 2016; 105 (03) e94-e98
    CrossrefPubMedSuche in Google Scholar
  • 8 Poets CF, Stebbens VA, Lang JA, O'Brien LM, Boon AW, Southall DP. Arterial oxygen saturation in healthy term neonates. Eur J Pediatr 1996; 155 (03) 219-223
    CrossrefPubMedSuche in Google Scholar
  • 9 O'Brien LM, Stebbens VA, Poets CF, Heycock EG, Southall DP. Oxygen saturation during the first 24 hours of life. Arch Dis Child Fetal Neonatal Ed 2000; 83 (01) F35-F38
    CrossrefPubMedSuche in Google Scholar
  • 10 R Core Team. R: A language and environment for statistical computing. R Foundation for statistical computing. Accessed Aril 13, 2022 at: https://www.gbif.org/tool/81287/r-a-language-and-environment-for-statistical-computing
    PubMed
  • 11 Stebbens VA, Poets CF, Alexander JR, Arrowsmith WA, Southall DP. Oxygen saturation and breathing patterns in infancy. 1: full term infants in the second month of life. Arch Dis Child 1991; 66 (05) 569-573
    CrossrefPubMedSuche in Google Scholar
  • 12 Poets CF, Stebbens VA, Southall DP. Arterial oxygen saturation and breathing movements during the first year of life. J Dev Physiol 1991; 15 (06) 341-345
    PubMedSuche in Google Scholar
  • 13 Poets CF, Stebbens VA, Samuels MP, Southall DP. Oxygen saturation and breathing patterns in children. Pediatrics 1993; 92 (05) 686-690
    CrossrefPubMedSuche in Google Scholar
  • 14 Hunt CE, Corwin MJ, Lister G. et al; Collaborative Home Infant Monitoring Evaluation (CHIME) Study Group. Longitudinal assessment of hemoglobin oxygen saturation in healthy infants during the first 6 months of age. J Pediatr 1999; 135 (05) 580-586
    CrossrefPubMedSuche in Google Scholar
  • 15 Poets CF. Assessing oxygenation in healthy infants. J Pediatr 1999; 135 (05) 541-543
    CrossrefPubMedSuche in Google Scholar