Nucleus Accumbens Deep Brain Stimulation for Alcohol Addiction – Safety and Clinical Long-term Results of a Pilot Trial

U. J. Müller; V. Sturm; J. Voges; H.-J. Heinze; I. Galazky; L. Büntjen; M. Heldmann; T. Frodl; J. Steiner; B. Bogerts

doi:10.1055/s-0042-104507

Pharmacopsychiatry, Inhaltsverzeichnis

Pharmacopsychiatry 2016; 49(04): 170-173
DOI: 10.1055/s-0042-104507

Original Paper

Nucleus Accumbens Deep Brain Stimulation for Alcohol Addiction – Safety and Clinical Long-term Results of a Pilot Trial

U. J. Müller

¹Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Magdeburg

,

V. Sturm

²Department of Stereotaxy and Functional Neurosurgery, University of Cologne, Cologne

,

J. Voges

³Department of Stereotactic Neurosurgery, Otto-von-Guericke-University of Magdeburg, Magdeburg

,

H.-J. Heinze

⁴Department of Neurology, Otto-von-Guericke-University of Magdeburg, Magdeburg

,

I. Galazky

⁴Department of Neurology, Otto-von-Guericke-University of Magdeburg, Magdeburg

,

L. Büntjen

³Department of Stereotactic Neurosurgery, Otto-von-Guericke-University of Magdeburg, Magdeburg

,

M. Heldmann

⁴Department of Neurology, Otto-von-Guericke-University of Magdeburg, Magdeburg

,

T. Frodl

¹Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Magdeburg

,

J. Steiner

¹Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Magdeburg

,

B. Bogerts

¹Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Magdeburg

› Institutsangaben

Abstract

We report on the long-term clinical outcome (up to 8 years) of 5 patients who received deep brain stimulation (DBS) of the nucleus accumbens to treat their long-lasting and treatment-resistant alcohol addiction. All patients reported a complete absence of craving for alcohol; 2 patients remained abstinent for many years and 3 patients showed a marked reduction of alcohol consumption. No severe or long-standing side effects occurred. Therefore, DBS could be a promising, novel treatment option for severe alcohol addiction, but larger clinical trials are needed to further investigate the efficacy of DBS in addiction.

Key words

alcohol addiction - deep brain stimulation - nucleus accumbens - craving

Volltext

Referenzen

References
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